RS-67,333 explained

RS-67,333 is a drug which has been investigated as a potential rapid-acting antidepressant,^[1] nootropic,^[2] and treatment for Alzheimer's disease.^[3] It is a high-affinity 5-HT4 receptor partial agonist, as well as a sigma receptor ligand of both subtypes to a lesser extent.^[4]

Notes and References

1. Lucas G, Rymar VV, Du J, Mnie-Filali O, Bisgaard C, Manta S, Lambas-Senas L, Wiborg O, Haddjeri N, Piñeyro G, Sadikot AF, Debonnel G . Serotonin(4) (5-HT(4)) Receptor Agonists Are Putative Antidepressants with a Rapid Onset of Action. . Neuron . 2007 . 712 - 25 . 55 . 5 . 17785179 . 10.1016/j.neuron.2007.07.041. 14558104 . free .
2. Lamirault L, Simon H . Enhancement of place and object recognition memory in young adult and old rats by RS 67333, a partial agonist of 5-HT4 receptors. . Neuropharmacology . 2001 . 844 - 53 . 41 . 7 . 11684148 . 10.1016/S0028-3908(01)00123-X. 31707593 .
3. Cho S, Hu Y . Activation of 5-HT4 receptors inhibits secretion of beta-amyloid peptides and increases neuronal survival. . Experimental Neurology . 2007 . 274 - 8 . 203 . 1 . 16978609 . 10.1016/j.expneurol.2006.07.021. 41975593 .
4. Eglen RM, Bonhaus DW, Johnson LG, Leung E, Clark RD . Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo . Br. J. Pharmacol. . 115 . 8 . 1387–92 . August 1995 . 8564196 . 1908873 . 10.1111/j.1476-5381.1995.tb16628.x.