RRP15 explained

RRP15-like protein is a protein that in humans is encoded by the RRP15 gene.^{[1] [2]}

This gene encodes a protein that co-purifies with human nucleoli. A similar protein in budding yeast is a component of pre-60S ribosomal particles, and is required for the early maturation steps of the 60S subunit.

Further reading

• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Beausoleil SA, Jedrychowski M, Schwartz D, etal . Large-scale characterization of HeLa cell nuclear phosphoproteins. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . 2004PNAS..10112130B . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Andersen JS, Lyon CE, Fox AH, etal . Directed proteomic analysis of the human nucleolus. . Curr. Biol. . 12 . 1 . 1–11 . 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9 . 14132033 . free . 2002CBio...12....1A .
• Lai CH, Chou CY, Ch'ang LY, etal . Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. . Genome Res. . 10 . 5 . 703–13 . 2000 . 10810093 . 10.1101/gr.10.5.703 . 310876 .
• Seki N, Ohira M, Nagase T, etal . Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. . DNA Res. . 4 . 5 . 345–9 . 1998 . 9455484 . 10.1093/dnares/4.5.345 . free .

Notes and References

1. De Marchis ML, Giorgi A, Schinina ME, Bozzoni I, Fatica A . Rrp15p, a novel component of pre-ribosomal particles required for 60S ribosome subunit maturation . RNA . 11 . 4 . 495–502 . Mar 2005 . 15769876 . 1370738 . 10.1261/rna.7200205 .
2. Web site: Entrez Gene: RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae).