RRP1 explained

Ribosomal RNA processing protein 1 homolog A is a protein that in humans is encoded by the RRP1 gene.^{[1] [2] [3]}

The protein encoded by this gene is the putative homolog of the yeast ribosomal RNA processing protein RRP1. The encoded protein is involved in the late stages of nucleologenesis at the end of mitosis, and may be required for the generation of 28S rRNA.

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Jansen E, Meulemans SM, Orlans IC, Van de Ven WJ . The NNP-1 gene (D21S2056E), which encodes a novel nuclear protein, maps in close proximity to the cystatin B gene within the EPM1 and APECED critical region on 21q22.3. . Genomics . 42 . 2 . 336–41 . 1997 . 9192856 . 10.1006/geno.1997.4755 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Andersen JS, Lyon CE, Fox AH, etal . Directed proteomic analysis of the human nucleolus. . Curr. Biol. . 12 . 1 . 1–11 . 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9 . 14132033 . free . 2002CBio...12....1A .
• Behrends U, Jandl T, Golbeck A, etal . Novel products of the HUD, HUC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library. . Int. J. Cancer . 100 . 6 . 669–77 . 2002 . 12209604 . 10.1002/ijc.10550 . 35369661 . free .
• Scherl A, Couté Y, Déon C, etal . Functional proteomic analysis of human nucleolus. . Mol. Biol. Cell . 13 . 11 . 4100–9 . 2003 . 12429849 . 10.1091/mbc.E02-05-0271 . 133617 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
• Hu YH, Warnatz HJ, Vanhecke D, etal . Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. . BMC Genomics . 7. 155 . 2006 . 16780588 . 10.1186/1471-2164-7-155 . 1526728 . free .

Notes and References

1. Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML . The DNA sequence of human chromosome 21 . Nature . 405 . 6784 . 311–9 . Jun 2000 . 10830953 . 10.1038/35012518 . 2000Natur.405..311H . free .
2. Savino TM, Bastos R, Jansen E, Hernandez-Verdun D . The nucleolar antigen Nop52, the human homologue of the yeast ribosomal RNA processing RRP1, is recruited at late stages of nucleologenesis . 112 . J Cell Sci . (Pt 12) . 1889–900 . Aug 1999 . 12 . 10.1242/jcs.112.12.1889 . 10341208 .
3. Web site: Entrez Gene: D21S2056E DNA segment on chromosome 21 (unique) 2056 expressed sequence.