RRN3 explained

RNA polymerase I-specific transcription initiation factor RRN3 is an enzyme that in humans is encoded by the RRN3 gene.^{[1] [2] [3]}

Interactions

RRN3 has been shown to interact with TAF1B.

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Bodem J, Dobreva G, Hoffmann-Rohrer U, Iben S, Zentgraf H, Delius H, Vingron M, Grummt I . TIF-IA, the factor mediating growth-dependent control of ribosomal RNA synthesis, is the mammalian homolog of yeast Rrn3p . EMBO Rep. . 1 . 2 . 171–5 . 2000 . 11265758 . 1084264 . 10.1093/embo-reports/kvd032.
• Yuan X, Zhao J, Zentgraf H, Hoffmann-Rohrer U, Grummt I . Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter . EMBO Rep. . 3 . 11 . 1082–7 . 2002 . 12393749 . 1307603 . 10.1093/embo-reports/kvf212 .
• Zhao J, Yuan X, Frödin M, Grummt I . ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth . Mol. Cell . 11 . 2 . 405–13 . 2003 . 12620228 . 10.1016/S1097-2765(03)00036-4 . free .
• Mayer C, Zhao J, Yuan X, Grummt I . mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability . Genes Dev. . 18 . 4 . 423–34 . 2004 . 15004009 . 359396 . 10.1101/gad.285504 .
• Philimonenko VV, Zhao J, Iben S, Dingová H, Kyselá K, Kahle M, Zentgraf H, Hofmann WA, de Lanerolle P, Hozák P, Grummt I . Nuclear actin and myosin I are required for RNA polymerase I transcription . Nat. Cell Biol. . 6 . 12 . 1165–72 . 2004 . 15558034 . 10.1038/ncb1190 . 6633625 .

Notes and References

1. Moorefield B, Greene EA, Reeder RH . RNA polymerase I transcription factor Rrn3 is functionally conserved between yeast and human . Proc. Natl. Acad. Sci. U.S.A. . 97 . 9 . 4724–9 . May 2000 . 10758157 . 18300 . 10.1073/pnas.080063997 . 2000PNAS...97.4724M . free .
2. Miller G, Panov KI, Friedrich JK, Trinkle-Mulcahy L, Lamond AI, Zomerdijk JC . hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters . EMBO J. . 20 . 6 . 1373–82 . Mar 2001 . 11250903 . 145519 . 10.1093/emboj/20.6.1373 .
3. Web site: Entrez Gene: RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae).