RRM1 explained

Ribonucleoside-diphosphate reductase large subunit is an enzyme that in humans is encoded by the RRM1 gene.^{[1] [2]}

This gene encodes one of two non-identical subunits which constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. This gene is oriented in a head-to-tail configuration with the stromal interaction molecule 1 gene (STIM1), with the 3' end of STIM1 situated 1.6 kb from the 5' end of this gene.^[2]

See also

• Ribonucleotide reductase

Further reading

• Pavloff N, Rivard D, Masson S, etal . Sequence analysis of the large and small subunits of human ribonucleotide reductase. . DNA Seq. . 2 . 4 . 227–34 . 1992 . 1627826 . 10.3109/10425179209020807 .
• Byrne J, Smith P . Human polymorphic probe pE1.8 detects SacI polymorphism in the ribonucleotide reductase M1 subunit gene. . Hum. Genet. . 87 . 3 . 376 . 1991 . 1677928 . 10.1007/BF00200924 . 9398850 .
• Parker NJ, Begley CG, Fox RM . Human M1 subunit of ribonucleotide reductase: cDNA sequence and expression in stimulated lymphocytes. . Nucleic Acids Res. . 19 . 13 . 3741 . 1991 . 1840662 . 10.1093/nar/19.13.3741 . 328406 .
• Mann GJ, Musgrove EA, Fox RM, Thelander L . Ribonucleotide reductase M1 subunit in cellular proliferation, quiescence, and differentiation. . Cancer Res. . 48 . 18 . 5151–6 . 1988 . 3044582 .
• Brissenden JE, Caras I, Thelander L, Francke U . The structural gene for the M1 subunit of ribonucleotide reductase maps to chromosome 11, band p15, in human and to chromosome 7 in mouse. . Exp. Cell Res. . 174 . 1 . 302–8 . 1988 . 3275546 . 10.1016/0014-4827(88)90165-6 .
• Engström Y, Francke U . Assignment of the structural gene for subunit M1 of human ribonucleotide reductase to the short arm of chromosome 11. . Exp. Cell Res. . 158 . 2 . 477–83 . 1985 . 3891388 . 10.1016/0014-4827(85)90470-7 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Parker NJ, Begley CG, Fox RM . Human R1 subunit of ribonucleotide reductase (RRM1): 5' flanking region of the gene . Genomics . 19 . 1 . 91–6 . 1994 . 8188248 . 10.1006/geno.1994.1017 .
• Byrne JA, Smith PJ . The 11p15.5 ribonucleotide reductase M1 subunit locus is not imprinted in Wilms' tumour and hepatoblastoma . Hum. Genet. . 91 . 3 . 275–7 . 1993 . 8386696 . 10.1007/BF00218271 . 22372180 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Bepler G, O'briant KC, Kim YC, etal . A 1.4-Mb high-resolution physical map and contig of chromosome segment 11p15.5 and genes in the LOH11A metastasis suppressor region . Genomics . 55 . 2 . 164–75 . 1999 . 9933563 . 10.1006/geno.1998.5659 .
• Pitterle DM, Kim YC, Jolicoeur EM, etal . Lung cancer and the human gene for ribonucleotide reductase subunit M1 (RRM1) . Mamm. Genome . 10 . 9 . 916–22 . 1999 . 10441745 . 10.1007/s003359901114 . 22700595 .
• Guittet O, Håkansson P, Voevodskaya N, etal . Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells . J. Biol. Chem. . 276 . 44 . 40647–51 . 2001 . 11517226 . 10.1074/jbc.M106088200 . 25065915 . free .
• Kashlan OB, Scott CP, Lear JD, Cooperman BS . A comprehensive model for the allosteric regulation of mammalian ribonucleotide reductase. Functional consequences of ATP- and dATP-induced oligomerization of the large subunit . Biochemistry . 41 . 2 . 462–74 . 2002 . 11781084 . 10.1021/bi011653a .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Kashlan OB, Cooperman BS . Comprehensive model for allosteric regulation of mammalian ribonucleotide reductase: refinements and consequences . Biochemistry . 42 . 6 . 1696–706 . 2003 . 12578384 . 10.1021/bi020634d .
• Xue L, Zhou B, Liu X, etal . Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits . Cancer Res. . 63 . 5 . 980–6 . 2003 . 12615712 .
• Gautam A, Li ZR, Bepler G . RRM1-induced metastasis suppression through PTEN-regulated pathways . Oncogene . 22 . 14 . 2135–42 . 2003 . 12687015 . 10.1038/sj.onc.1206232 . free .
• Rosell R, Scagliotti G, Danenberg KD, etal . Transcripts in pretreatment biopsies from a three-arm randomized trial in metastatic non-small-cell lung cancer . Oncogene . 22 . 23 . 3548–53 . 2003 . 12789263 . 10.1038/sj.onc.1206419 . free .

Notes and References

1. Parker NJ, Begley CG, Fox RM . Human gene for the large subunit of ribonucleotide reductase (RRM1): functional analysis of the promoter . Genomics . 27 . 2 . 280–5 . Nov 1995 . 7557993 . 10.1006/geno.1995.1043 .
2. Web site: Entrez Gene: RRM1 ribonucleotide reductase M1 polypeptide.