RREB1 explained

Ras-responsive element-binding protein 1 is a protein that in humans is encoded by the RREB1 gene.^{[1] [2] [3]}

Clinical significance

Mutations in RREB1 are associated to type 2 diabetes associated end-stage kidney disease.^[4]

Further reading

• Thiagalingam A . RREB-1, a novel zinc finger protein, is involved in the differentiation response to Ras in human medullary thyroid carcinomas . Mol. Cell. Biol. . 16 . 10 . 5335–45 . 1996 . 8816445 . 10.1128/mcb.16.10.5335. 231532 . De Bustros A . Borges M . Jasti . R . Compton . D . Diamond . L . Mabry . M . Ball . DW . Baylin . SB .
• Fujimoto-Nishiyama A . A novel zinc finger protein, Finb, is a transcriptional activator and localized in nuclear bodies . Gene . 195 . 2 . 267–275 . 1997 . 9305772 . 10.1016/S0378-1119(97)00172-8 . Ishii S . Matsuda S . Inoue . Jun-Ichiro . Yamamoto . Tadashi .
• Zhang L, Zhao J, Edenberg HJ . A human Raf-responsive zinc-finger protein that binds to divergent sequences . Nucleic Acids Res. . 27 . 14 . 2947–2956 . 1999 . 10390538 . 10.1093/nar/27.14.2947 . 148511 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Ray SK . Novel transcriptional potentiation of BETA2/NeuroD on the secretin gene promoter by the DNA-binding protein Finb/RREB-1 . Mol. Cell. Biol. . 23 . 1 . 259–271 . 2003 . 12482979 . 10.1128/MCB.23.1.259-271.2003 . 140679 . Nishitani J . Petry MW . Fessing . M. Y. . Leiter . A. B. .
• Zhang S . p16 INK4a gene promoter variation and differential binding of a repressor, the ras-responsive zinc-finger transcription factor, RREB . Oncogene . 22 . 15 . 2285–2295 . 2003 . 12700664 . 10.1038/sj.onc.1206257 . Qian X . Redman C . Bliskovski . Valeri . Ramsay . Edward S . Lowy . Douglas R . Mock . Beverly A . 917155 .
• Shi Y . Coordinated histone modifications mediated by a CtBP co-repressor complex . Nature . 422 . 6933 . 735–738 . 2003 . 12700765 . 10.1038/nature01550 . Sawada J . Sui G . Affar . El Bachir . Whetstine . Johnathan R. . Lan . Fei . Ogawa . Hidesato . Po-Shan Luke . Margaret . Nakatani . Yoshihiro . 2003Natur.422..735S . 2670859 .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–45 . 2004 . 14702039 . 10.1038/ng1285 . Suzuki Y . Nishikawa T . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Date S . Finb, a multiple zinc finger protein, represses transcription of the human angiotensinogen gene . Int. J. Mol. Med. . 13 . 5 . 637–42 . 2005 . 15067362 . 10.3892/ijmm.13.5.637. Nibu Y . Yanai K . Hirata . J . Yagami . K . Fukamizu . A .
• Beausoleil SA . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–12135 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . Jedrychowski M . Schwartz D . Elias . JE . Villén . J . Li . J . Cohn . MA . Cantley . LC . Gygi . SP . 2004PNAS..10112130B . free .

Notes and References

1. Thiagalingam A, Lengauer C, Baylin SB, Nelkin BD . RREB1, a ras responsive element binding protein, maps to human chromosome 6p25 . Genomics . 45 . 3 . 630–632 . Jan 1998 . 9367691 . 10.1006/geno.1997.5001 . free .
2. Melani M, Simpson KJ, Brugge JS, Montell D . Regulation of cell adhesion and collective cell migration by hindsight and its human homolog RREB1 . Curr Biol . 18 . 7 . 532–537 . Apr 2008 . 18394891 . 10.1016/j.cub.2008.03.024 . 17251337 . free . 2008CBio...18..532M .
3. Web site: Entrez Gene: RREB1 ras responsive element binding protein 1.
4. 25027322. 2014. Bonomo. J. A.. The ras responsive transcription factor RREB1 is a novel candidate gene for type 2 diabetes associated end-stage kidney disease. Human Molecular Genetics. Guan. M. Ng. M. C.. Palmer. N. D.. Hicks. P. J.. Keaton. J. M.. Lea. J. P.. Langefeld. C. D.. Freedman. B. I.. Bowden. D. W.. 10.1093/hmg/ddu362 . 23 . 24. 6441–7 . 4240197.