RRAS2 explained

Ras-related protein R-Ras2 is a protein that in humans is encoded by the RRAS2 gene.^{[1] [2] [3]}

Interactions

RRAS2 has been shown to interact with C-Raf.^{[4] [5]}

Further reading

• Ehrhardt A, Ehrhardt GR, Guo X, Schrader JW . Ras and relatives--job sharing and networking keep an old family together. . Exp. Hematol. . 30 . 10 . 1089–106 . 2002 . 12384139 . 10.1016/S0301-472X(02)00904-9 . free .
• Rosário M, Paterson HF, Marshall CJ . Activation of the Raf/MAP kinase cascade by the Ras-related protein TC21 is required for the TC21-mediated transformation of NIH 3T3 cells. . EMBO J. . 18 . 5 . 1270–9 . 1999 . 10064593 . 10.1093/emboj/18.5.1270 . 1171217 .
• Linnemann T, Geyer M, Jaitner BK, etal . Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily. . J. Biol. Chem. . 274 . 19 . 13556–62 . 1999 . 10224125 . 10.1074/jbc.274.19.13556 . free .
• Ehrhardt GR, Leslie KB, Lee F, etal . M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line. . Blood . 94 . 7 . 2433–44 . 1999 . 10498616 . 10.1182/blood.V94.7.2433.419k31_2433_2444. 40024826 .
• Movilla N, Crespo P, Bustelo XR . Signal transduction elements of TC21, an oncogenic member of the R-Ras subfamily of GTP-binding proteins. . Oncogene . 18 . 43 . 5860–9 . 1999 . 10557073 . 10.1038/sj.onc.1202968 . 31576945 .
• Ohba Y, Mochizuki N, Yamashita S, etal . Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3. . J. Biol. Chem. . 275 . 26 . 20020–6 . 2000 . 10777492 . 10.1074/jbc.M000981200 . free .
• Figueroa C, Taylor J, Vojtek AB . Prenylated Rab acceptor protein is a receptor for prenylated small GTPases. . J. Biol. Chem. . 276 . 30 . 28219–25 . 2001 . 11335720 . 10.1074/jbc.M101763200 . free .
• Murphy GA, Graham SM, Morita S, etal . Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation. . J. Biol. Chem. . 277 . 12 . 9966–75 . 2002 . 11788587 . 10.1074/jbc.M109059200 . free .
• Rong R, He Q, Liu Y, etal . TC21 mediates transformation and cell survival via activation of phosphatidylinositol 3-kinase/Akt and NF-kappaB signaling pathway. . Oncogene . 21 . 7 . 1062–70 . 2002 . 11850823 . 10.1038/sj.onc.1205154 . 21196767 . free .
• Ortiz-Vega S, Khokhlatchev A, Nedwidek M, etal . The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1. . Oncogene . 21 . 9 . 1381–90 . 2002 . 11857081 . 10.1038/sj.onc.1205192 . 240243 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Yuryev A, Wennogle LP . Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis. . Genomics . 81 . 2 . 112–25 . 2003 . 12620389 . 10.1016/S0888-7543(02)00008-3 .
• Mitin NY, Ramocki MB, Zullo AJ, etal . Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization. . J. Biol. Chem. . 279 . 21 . 22353–61 . 2004 . 15031288 . 10.1074/jbc.M312867200 . free .
• Kho Y, Kim SC, Jiang C, etal . A tagging-via-substrate technology for detection and proteomics of farnesylated proteins. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 34 . 12479–84 . 2004 . 15308774 . 10.1073/pnas.0403413101 . 515085 . 2004PNAS..10112479K . free .
• Suzuki Y, Yamashita R, Shirota M, etal . Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. . Genome Res. . 14 . 9 . 1711–8 . 2004 . 15342556 . 10.1101/gr.2435604 . 515316 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Barrios-Rodiles M, Brown KR, Ozdamar B, etal . High-throughput mapping of a dynamic signaling network in mammalian cells. . Science . 307 . 5715 . 1621–5 . 2005 . 15761153 . 10.1126/science.1105776 . 2005Sci...307.1621B . 39457788 .

Notes and References

1. Drivas GT, Shih A, Coutavas E, Rush MG, D'Eustachio P . Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line . Mol Cell Biol . 10 . 4 . 1793–8 . May 1990 . 2108320 . 362288 . 10.1128/mcb.10.4.1793.
2. Chan AM, Miki T, Meyers KA, Aaronson SA . A human oncogene of the RAS superfamily unmasked by expression cDNA cloning . Proc Natl Acad Sci U S A . 91 . 16 . 7558–62 . September 1994 . 8052619 . 44441 . 10.1073/pnas.91.16.7558 . 1994PNAS...91.7558C . free .
3. Web site: Entrez Gene: RRAS2 related RAS viral (r-ras) oncogene homolog 2.
4. Li . W . Han M . Guan K L . April 2000 . The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf . Genes Dev. . 14 . 8 . 895–900 . UNITED STATES. 10.1101/gad.14.8.895 . 0890-9369. 10783161 . 316541 .
5. Movilla . N . Crespo P . Bustelo X R . October 1999 . Signal transduction elements of TC21, an oncogenic member of the R-Ras subfamily of GTP-binding proteins . Oncogene . 18 . 43 . 5860–9 . ENGLAND. 0950-9232. 10557073 . 10.1038/sj.onc.1202968 . 31576945 .