40S ribosomal protein S7 explained

40S ribosomal protein S7 is a protein that in humans is encoded by the RPS7 gene.^{[1] [2]}

In eukaryotes, ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[3]

Further reading

• Wool IG, Chan YL, Glück A . Structure and evolution of mammalian ribosomal proteins. . Biochem. Cell Biol. . 73 . 11–12 . 933–47 . 1996 . 8722009 . 10.1139/o95-101 .
• Mundus DA, Bulygin KN, Yamkovoy VI, etal . Structural arrangement of the codon-anticodon interaction area in human placenta ribosomes. Affinity labelling of the 40S subunits by derivatives of oligoribonucleotides containing the AUG codon . Biochim. Biophys. Acta . 1173 . 3 . 273–82 . 1993 . 8318536 . 10.1016/0167-4781(93)90124-v.
• Vladimirov SN, Ivanov AV, Karpova GG, etal . Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry . Eur. J. Biochem. . 239 . 1 . 144–9 . 1996 . 8706699 . 10.1111/j.1432-1033.1996.0144u.x . free .
• Kenmochi N, Kawaguchi T, Rozen S, etal . A map of 75 human ribosomal protein genes . Genome Res. . 8 . 5 . 509–23 . 1998 . 9582194 . 10.1101/gr.8.5.509. free .
• Jäkel S, Görlich D . Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells . EMBO J. . 17 . 15 . 4491–502 . 1998 . 9687515 . 10.1093/emboj/17.15.4491 . 1170780 .
• Jäkel S, Mingot JM, Schwarzmaier P, etal . Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains . EMBO J. . 21 . 3 . 377–86 . 2002 . 11823430 . 10.1093/emboj/21.3.377 . 125346 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Yu Y, Ji H, Doudna JA, Leary JA . Mass spectrometric analysis of the human 40S ribosomal subunit: Native and HCV IRES-bound complexes . Protein Sci. . 14 . 6 . 1438–46 . 2005 . 15883184 . 10.1110/ps.041293005 . 2253395 .
• Tompkins V, Hagen J, Zediak VP, Quelle DE . Identification of novel ARF binding proteins by two-hybrid screening . Cell Cycle . 5 . 6 . 641–6 . 2006 . 16582619 . 10.4161/cc.5.6.2560. free .
• Chen D, Zhang Z, Li M, etal . Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function . Oncogene . 26 . 35 . 5029–37 . 2007 . 17310983 . 10.1038/sj.onc.1210327 . 9239498 .

Notes and References

1. Annilo T, Laan M, Stahl J, Metspalu A . The human ribosomal protein S7-encoding gene: isolation, structure and localization in 2p25 . Gene . 165 . 2 . 297–302 . Jan 1996 . 8522193 . 10.1016/0378-1119(95)00576-R .
2. Gorbea C, Taillandier D, Rechsteiner M . Mapping subunit contacts in the regulatory complex of the 26 S proteasome. S2 and S5b form a tetramer with ATPase subunits S4 and S7 . J Biol Chem . 275 . 2 . 875–82 . Feb 2000 . 10625621 . 10.1074/jbc.275.2.875 . free .
3. Web site: Entrez Gene: RPS7 ribosomal protein S7.