RPS6KA4 explained

Ribosomal protein S6 kinase alpha-4 is an enzyme that in humans is encoded by the RPS6KA4 gene.^{[1] [2] [3]}

Function

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-Fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.^[3]

Interactions

RPS6KA4 has been shown to interact with MAPK14.^[1]

Further reading

• Xing J, Ginty DD, Greenberg ME . Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase . Science . 273 . 5277 . 959–963 . 1996 . 8688081 . 10.1126/science.273.5277.959 . 1996Sci...273..959X . 22226803 .
• Du K, Montminy M . CREB is a regulatory target for the protein kinase Akt/PKB . J. Biol. Chem. . 273 . 49 . 32377–32379 . 1999 . 9829964 . 10.1074/jbc.273.49.32377 . free .
• Tomás-Zuber M, Mary JL, Lesslauer W . Control sites of ribosomal S6 kinase B and persistent activation through tumor necrosis factor . J. Biol. Chem. . 275 . 31 . 23549–23558 . 2000 . 10806207 . 10.1074/jbc.M002586200 . free .
• Tomás-Zuber M . C-terminal elements control location, activation threshold, and p38 docking of ribosomal S6 kinase B (RSKB) . J. Biol. Chem. . 276 . 8 . 5892–5899 . 2001 . 11035004 . 10.1074/jbc.M005822200 . vanc. Mary JL . Lamour F . 3 . Bur . D . Lesslauer . W . free .
• Gudi T . NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation . Oncogene . 19 . 54 . 6324–6333 . 2001 . 11175347 . 10.1038/sj.onc.1204007 . vanc. Casteel DE . Vinson C . 3 . Boss . Gerry R . Pilz . Renate B . free .
• Prymakowska-Bosak M . Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin . Mol. Cell. Biol. . 21 . 15 . 5169–5178 . 2001 . 11438671 . 10.1128/MCB.21.15.5169-5178.2001 . 87241 . vanc. Misteli T . Herrera JE . 3 . Shirakawa . H. . Birger . Y. . Garfield . S. . Bustin . M. .
• Wiggin GR . MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts . Mol. Cell. Biol. . 22 . 8 . 2871–2881 . 2002 . 11909979 . 10.1128/MCB.22.8.2871-2881.2002 . 133730 . vanc. Soloaga A . Foster JM . 3 . Murray-Tait . V. . Cohen . P. . Arthur . J. S. C. .
• Soloaga A . MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14 . EMBO J. . 22 . 11 . 2788–2797 . 2003 . 12773393 . 10.1093/emboj/cdg273 . 156769 . vanc. Thomson S . Wiggin GR . 3 . Rampersaud . N . Dyson . MH . Hazzalin . CA . Mahadevan . LC . Arthur . JS .
• Wissing J . Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry . Mol. Cell. Proteomics . 6 . 3 . 537–547 . 2007 . 17192257 . 10.1074/mcp.T600062-MCP200 . vanc. Jänsch L . Nimtz M . 3 . Dieterich . G. . Hornberger . R. . Keri . G. . Wehland . J. . Daub . H. . free . 10033/19756 . free .
• Gesser B . Dimethylfumarate specifically inhibits the mitogen and stress-activated kinases 1 and 2 (MSK1/2): possible role for its anti-psoriatic effect . J. Invest. Dermatol. . 127 . 9 . 2129–2137 . 2007 . 17495961 . 10.1038/sj.jid.5700859 . vanc. Johansen C . Rasmussen MK . 3 . Funding . Anne T . Otkjaer . Kristian . Kjellerup . Rasmus B . Kragballe . Knud . Iversen . Lars . free .

Notes and References

1. Pierrat B, Correia JS, Mary JL, Tomas-Zuber M, Lesslauer W . RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK) . J Biol Chem . 273 . 45 . 29661–29671 . Dec 1998 . 9792677 . 10.1074/jbc.273.45.29661 . free .
2. Deak M, Clifton AD, Lucocq LM, Alessi DR . Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB . EMBO J . 17 . 15 . 4426–4441 . Sep 1998 . 9687510 . 1170775 . 10.1093/emboj/17.15.4426 .
3. Web site: Entrez Gene: RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4.