RPS6KA2 explained

Ribosomal protein S6 kinase alpha-2 is an enzyme that in humans is encoded by the RPS6KA2 gene.^{[1] [2]}

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine and threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Interactions

RPS6KA2 has been shown to interact with MAPK3^{[3] [4]} and MAPK1.^{[3] [4]}

Further reading

• Dawson SJ, White LA . Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin . J. Infect. . 24 . 3 . 317–20 . 1992 . 1602151 . 10.1016/S0163-4453(05)80037-4 .
• Zhao Y, Bjørbaek C, Weremowicz S, etal . RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation . Mol. Cell. Biol. . 15 . 8 . 4353–63 . 1995 . 7623830 . 10.1128/MCB.15.8.4353. 230675 .
• Wong EV, Schaefer AW, Landreth G, Lemmon V . Involvement of p90rsk in neurite outgrowth mediated by the cell adhesion molecule L1 . J. Biol. Chem. . 271 . 30 . 18217–23 . 1996 . 8663493 . 10.1074/jbc.271.30.18217 . free .
• Xing J, Ginty DD, Greenberg ME . Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase . Science . 273 . 5277 . 959–63 . 1996 . 8688081 . 10.1126/science.273.5277.959 . 1996Sci...273..959X . 22226803 .
• Zhao Y, Bjorbaek C, Moller DE . Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases . J. Biol. Chem. . 271 . 47 . 29773–9 . 1997 . 8939914 . 10.1074/jbc.271.47.29773 . free .
• Fukunaga R, Hunter T . MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates . EMBO J. . 16 . 8 . 1921–33 . 1997 . 9155018 . 10.1093/emboj/16.8.1921 . 1169795 .
• del Peso L, González-García M, Page C, etal . Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt . Science . 278 . 5338 . 687–9 . 1997 . 9381178 . 10.1126/science.278.5338.687 . 1997Sci...278..687D .
• Deak M, Clifton AD, Lucocq LM, Alessi DR . Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB . EMBO J. . 17 . 15 . 4426–41 . 1998 . 9687510 . 10.1093/emboj/17.15.4426 . 1170775 .
• Du K, Montminy M . CREB is a regulatory target for the protein kinase Akt/PKB . J. Biol. Chem. . 273 . 49 . 32377–9 . 1999 . 9829964 . 10.1074/jbc.273.49.32377 . free .
• Smith JA, Poteet-Smith CE, Malarkey K, Sturgill TW . Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo . J. Biol. Chem. . 274 . 5 . 2893–8 . 1999 . 9915826 . 10.1074/jbc.274.5.2893 . free .
• Jensen CJ, Buch MB, Krag TO, etal . 90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1 . J. Biol. Chem. . 274 . 38 . 27168–76 . 1999 . 10480933 . 10.1074/jbc.274.38.27168 . free .
• Schimenti JC . ORFless, intronless, and mutant transcription units in the mouse t complex responder (Tcr) locus . Mamm. Genome . 10 . 10 . 969–76 . 2000 . 10501965 . 10.1007/s003359901142 . 23157540 .
• Scheid MP, Schubert KM, Duronio V . Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase . J. Biol. Chem. . 274 . 43 . 31108–13 . 1999 . 10521512 . 10.1074/jbc.274.43.31108 . free .
• Tan Y, Demeter MR, Ruan H, Comb MJ . BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival . J. Biol. Chem. . 275 . 33 . 25865–9 . 2000 . 10837486 . 10.1074/jbc.M004199200 . free .
• Lizcano JM, Morrice N, Cohen P . Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155 . Biochem. J. . 349 . Pt 2 . 547–57 . 2001 . 10880354 . 10.1042/0264-6021:3490547 . 1221178 .
• Datta SR, Katsov A, Hu L, etal . 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation . Mol. Cell . 6 . 1 . 41–51 . 2000 . 10949026 . 10.1016/S1097-2765(00)00006-X . free .
• Gudi T, Casteel DE, Vinson C, etal . NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation . Oncogene . 19 . 54 . 6324–33 . 2001 . 11175347 . 10.1038/sj.onc.1204007 . 20150481 .
• Willard FS, Crouch MF . MEK, ERK, and p90RSK are present on mitotic tubulin in Swiss 3T3 cells: a role for the MAP kinase pathway in regulating mitotic exit . Cell. Signal. . 13 . 9 . 653–64 . 2001 . 11495723 . 10.1016/S0898-6568(01)00185-1 .
• Schinelli S, Zanassi P, Paolillo M, etal . Stimulation of endothelin B receptors in astrocytes induces cAMP response element-binding protein phosphorylation and c-fos expression via multiple mitogen-activated protein kinase signaling pathways . J. Neurosci. . 21 . 22 . 8842–53 . 2001 . 11698596 . 10.1523/JNEUROSCI.21-22-08842.2001. 6762276 .

Notes and References

1. Moller DE, Xia CH, Tang W, Zhu AX, Jakubowski M . Human rsk isoforms: cloning and characterization of tissue-specific expression . Am J Physiol . 266 . 2 Pt 1 . C351–9 . Apr 1994 . 8141249 . 10.1152/ajpcell.1994.266.2.C351.
2. Web site: Entrez Gene: RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2.
3. Roux . Philippe P . Richards Stephanie A . Blenis John . Jul 2003 . Phosphorylation of p90 Ribosomal S6 Kinase (RSK) Regulates Extracellular Signal-Regulated Kinase Docking and RSK Activity . Mol. Cell. Biol. . 23 . 14 . 4796–804 . United States. 0270-7306. 12832467 . 10.1128/MCB.23.14.4796-4804.2003 . 162206 .
4. Zhao . Y . Bjorbaek C . Moller D E . Nov 1996 . Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases . J. Biol. Chem. . 271 . 47 . 29773–9 . UNITED STATES. 0021-9258. 8939914 . 10.1074/jbc.271.47.29773 . free .