40S ribosomal protein S15 explained

40S ribosomal protein S15 is a protein that in humans is encoded by the RPS15 gene.^{[1] [2]}

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19P family of ribosomal proteins. It is located in the cytoplasm. This gene has been found to be activated in various tumors, such as insulinomas, esophageal cancers, and colon cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[2]

Further reading

• Wool IG, Chan YL, Glück A . Structure and evolution of mammalian ribosomal proteins. . Biochem. Cell Biol. . 73 . 11–12 . 933–47 . 1996 . 8722009 . 10.1139/o95-101 .
• Kitagawa M, Takasawa S, Kikuchi N, etal . rig encodes ribosomal protein S15. The primary structure of mammalian ribosomal protein S15 . FEBS Lett. . 283 . 2 . 210–4 . 1991 . 2044758 . 10.1016/0014-5793(91)80590-Y . 2687455 . free . 1991FEBSL.283..210K .
• Inoue C, Shiga K, Takasawa S, etal . Evolutionary conservation of the insulinoma gene rig and its possible function . Proc. Natl. Acad. Sci. U.S.A. . 84 . 19 . 6659–62 . 1987 . 2821540 . 10.1073/pnas.84.19.6659 . 299142 . 1987PNAS...84.6659I . free .
• Marion MJ, Marion C . Ribosomal proteins S2, S6, S10, S14, S15 and S25 are localized on the surface of mammalian 40 S subunits and stabilize their conformation. A study with immobilized trypsin . FEBS Lett. . 232 . 2 . 281–5 . 1988 . 3378620 . 10.1016/0014-5793(88)80753-1 . 44333810 . free . 1988FEBSL.232..281M .
• Vladimirov SN, Ivanov AV, Karpova GG, etal . Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry . Eur. J. Biochem. . 239 . 1 . 144–9 . 1996 . 8706699 . 10.1111/j.1432-1033.1996.0144u.x . free .
• Kenmochi N, Kawaguchi T, Rozen S, etal . A map of 75 human ribosomal protein genes . Genome Res. . 8 . 5 . 509–23 . 1998 . 9582194 . 10.1101/gr.8.5.509. free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Lehner B, Sanderson CM . A protein interaction framework for human mRNA degradation . Genome Res. . 14 . 7 . 1315–23 . 2004 . 15231747 . 10.1101/gr.2122004 . 442147 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Yu Y, Ji H, Doudna JA, Leary JA . Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes . Protein Sci. . 14 . 6 . 1438–46 . 2005 . 15883184 . 10.1110/ps.041293005 . 2253395 .

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human 40S ribosomal protein S15

Notes and References

1. Shiga K, Yamamoto H, Okamoto H . Isolation and characterization of the human homologue of rig and its pseudogenes: the functional gene has features characteristic of housekeeping genes . Proc Natl Acad Sci U S A . 87 . 9 . 3594–8 . Jun 1990 . 2159154 . 53948 . 10.1073/pnas.87.9.3594 . 1990PNAS...87.3594S . free .
2. Web site: Entrez Gene: RPS15 ribosomal protein S15.