40S ribosomal protein S10 explained

40S ribosomal protein S10 is a protein that in humans is encoded by the RPS10 gene.^{[1] [2] [3]}

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S10E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[3]

Clinical significance

Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found.^[3] Mutations in the RPS10 gene can cause Diamond–Blackfan anemia, a congenital anemia sometimes associated with bone marrow failure.^[4]

Interactions

RPS10 has been shown to interact with PTTG1.^[5]

Further reading

• Wool IG, Chan YL, Glück A . Structure and evolution of mammalian ribosomal proteins. . Biochem. Cell Biol. . 73 . 11–12 . 933–47 . 1996 . 8722009 . 10.1139/o95-101 .
• Vladimirov SN . Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry . Eur. J. Biochem. . 239 . 1 . 144–9 . 1996 . 8706699 . 10.1111/j.1432-1033.1996.0144u.x . vanc. Ivanov AV . Karpova GG . 3 . Musolyamov . Alekxander K. . Egorov . Tsezi A. . Thiede . Bernd . Wittmann-Liebold . Brigitte . Otto . Albrecht . free .
• Pei L . Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells . J. Biol. Chem. . 274 . 5 . 3151–8 . 1999 . 9915854 . 10.1074/jbc.274.5.3151 . free .
• Malygin AA, Shaulo DD, Karpova GG . Proteins S7, S10, S16 and S19 of the human 40S ribosomal subunit are most resistant to dissociation by salt . Biochim. Biophys. Acta . 1494 . 3 . 213–6 . 2001 . 11121577 . 10.1016/s0167-4781(00)00252-9.
• Bortoluzzi S, d'Alessi F, Romualdi C, Danieli GA . Differential expression of genes coding for ribosomal proteins in different human tissues . Bioinformatics . 17 . 12 . 1152–7 . 2002 . 11751223 . 10.1093/bioinformatics/17.12.1152 . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M. free .
• Malygin A, Baranovskaya O, Ivanov A, Karpova G . Expression and purification of human ribosomal proteins S3, S5, S10, S19, and S26 . Protein Expr. Purif. . 28 . 1 . 57–62 . 2003 . 12651107 . 10.1016/S1046-5928(02)00652-6 .
• Ballif BA . Phosphoproteomic analysis of the developing mouse brain . Mol. Cell. Proteomics . 3 . 11 . 1093–101 . 2005 . 15345747 . 10.1074/mcp.M400085-MCP200 . vanc. Villén J . Beausoleil SA . 3 . Schwartz . D . Gygi . SP . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Rush J . Immunoaffinity profiling of tyrosine phosphorylation in cancer cells . Nat. Biotechnol. . 23 . 1 . 94–101 . 2005 . 15592455 . 10.1038/nbt1046 . vanc. Moritz A . Lee KA . 3 . Guo . Ailan . Goss . Valerie L . Spek . Erik J . Zhang . Hui . Zha . Xiang-Ming . Polakiewicz . Roberto D . 7200157 .
• Andersen JS . Nucleolar proteome dynamics . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . vanc. Lam YW . Leung AK . 3 . Ong . Shao-En . Lyon . Carol E. . Lamond . Angus I. . Mann . Matthias . 2005Natur.433...77A. 4344740 .
• Yu Y, Ji H, Doudna JA, Leary JA . Mass spectrometric analysis of the human 40S ribosomal subunit: Native and HCV IRES-bound complexes . Protein Sci. . 14 . 6 . 1438–46 . 2005 . 15883184 . 10.1110/ps.041293005 . 2253395 .
• Stelzl U . A human protein-protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–68 . 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . vanc. Worm U . Lalowski M . 3 . Haenig . Christian . Brembeck . Felix H. . Goehler . Heike . Stroedicke . Martin . Zenkner . Martina . Schoenherr . Anke . free . 11858/00-001M-0000-0010-8592-0 . free .
• Ewing RM . Large-scale mapping of human protein–protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . vanc. Chu P . Elisma F . 3 . Li . Hongyan . Taylor . Paul . Climie . Shane . McBroom-Cerajewski . Linda . Robinson . Mark D . O'Connor . Liam .

External links

• GeneReviews/NCBI/NIH/UW entry on Diamond–Blackfan Anemia
• OMIM entries on Diamond–Blackfan Anemia

Notes and References

1. Frigerio JM, Dagorn JC, Iovanna JL . Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs . Biochim Biophys Acta . 1262 . 1 . 64–8 . Jul 1995 . 7772601 . 10.1016/0167-4781(95)00045-i.
2. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC . A map of 75 human ribosomal protein genes . Genome Res . 8 . 5 . 509–23 . Aug 1998 . 9582194 . 10.1101/gr.8.5.509. free .
3. Web site: Entrez Gene: RPS10 ribosomal protein S10.
4. Doherty . L . Sheen . MR . Vlachos . A . Choesmel . V . O'Donohue . MF . Clinton . C . Schneider . HE . Sieff . CA . Newburger . PE . Ball . SE . Niewiadomska . E . Matysiak . M . Glader . B . Arceci . RJ . Farrar . JE . Atsidaftos . E . Lipton . JM . Gleizes . PE . Gazda . Feb 2010 . Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond–Blackfan anemia. HT. . Am J Hum Genet . 86 . 2. 222–8 . 10.1016/j.ajhg.2009.12.015 . 20116044 . 2820177 .
5. Pei . L . Jan 1999 . Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells . J. Biol. Chem. . 274 . 5 . 3151–8 . 0021-9258. 9915854 . 10.1074/jbc.274.5.3151 . free .