60S ribosomal protein L6 explained

60S ribosomal protein L6 is a protein that in humans is encoded by the RPL6 gene.^{[1] [2] [3]}

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L6E family of ribosomal proteins. It is located in the cytoplasm. The protein can bind specifically to domain C of the tax-responsive enhancer element of human T-cell leukemia virus type 1, and it has been suggested that the protein may participate in tax-mediated transactivation of transcription. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.^[3]

Interactions

RPL6 has been shown to interact with Basic fibroblast growth factor.^[4]

Further reading

• Wool IG, Chan YL, Glück A . Structure and evolution of mammalian ribosomal proteins . Biochem. Cell Biol. . 73 . 11–12 . 933–47 . 1996 . 8722009 . 10.1139/o95-101 .
• Nika H, Hultin T . Location of the sulfhydryl groups involved in disulfide interaction between the neighboring proteins L6 and L29 in mammalian ribosomes. S-cleavage of the cyanylated proteins in polyacrylamide gels after separation by dodecylsulfate gel electrophoresis . Eur. J. Biochem. . 142 . 3 . 521–6 . 1984 . 6468376 . 10.1111/j.1432-1033.1984.tb08316.x . free .
• Todokoro K, Ulbrich N, Chan YL, Wool IG . Characterization of the binding of rat liver ribosomal proteins L6, L8, L19, S9, and S13 to 5.8 S ribosomal ribonucleic acid . J. Biol. Chem. . 256 . 14 . 7207–12 . 1981 . 10.1016/S0021-9258(19)68949-0 . 7251593 . free .
• Kato S . Construction of a human full-length cDNA bank . Gene . 150 . 2 . 243–50 . 1995 . 7821789 . 10.1016/0378-1119(94)90433-2 . vanc. Sekine S . Oh SW . 3 . Nam-Soon . Kim . Yuri . Umezawa . Naoto . Abe . Midori . Yokoyama-Kobayashi . Takashi . Aoki .
• Ohta K, Endo T, Gunji K, Onaya T . Isolation of a cDNA whose expression is markedly increased in malignantly transformed FRTL cells and neoplastic human thyroid tissues . J. Mol. Endocrinol. . 12 . 1 . 85–92 . 1994 . 8185817 . 10.1677/jme.0.0120085 .
• Monk S . Refined genetic mapping of the darier locus to a <1-cM region of chromosome 12q24.1, and construction of a complete, high-resolution P1 artificial chromosome/bacterial artificial chromosome contig of the critical region . Am. J. Hum. Genet. . 62 . 4 . 890–903 . 1998 . 9529352 . 10.1086/301794 . 1377034 . vanc. Sakuntabhai A . Carter SA . 3 . Bryce . S . Cox . R . Harrington . L . Levy . E . Ruizperez . V . Katsantoni . E .
• Kenmochi N . A map of 75 human ribosomal protein genes . Genome Res. . 8 . 5 . 509–23 . 1998 . 9582194 . 10.1101/gr.8.5.509 . vanc. Kawaguchi T . Rozen S . 3 . Davis . E . Goodman . N . Hudson . TJ . Tanaka . T . Page . DC. free .
• Shen B, Arese M, Gualandris A, Rifkin DB . Intracellular association of FGF-2 with the ribosomal protein L6/TAXREB107 . Biochem. Biophys. Res. Commun. . 252 . 2 . 524–8 . 1998 . 9826564 . 10.1006/bbrc.1998.9677 . free .
• Ye Z, Connor JR . cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs . Biochem. Biophys. Res. Commun. . 275 . 1 . 223–7 . 2000 . 10944468 . 10.1006/bbrc.2000.3282 .
• Kenmochi N, Yoshihama M, Higa S, Tanaka T . The human ribosomal protein L6 gene in a critical region for Noonan syndrome . J. Hum. Genet. . 45 . 5 . 290–3 . 2000 . 11043511 . 10.1007/s100380070018 . free .
• Uechi T, Tanaka T, Kenmochi N . A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders . Genomics . 72 . 3 . 223–30 . 2001 . 11401437 . 10.1006/geno.2000.6470 .
• Andersen JS . Directed proteomic analysis of the human nucleolus . Curr. Biol. . 12 . 1 . 1–11 . 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9 . vanc. Lyon CE . Fox AH . 3 . Leung . Anthony K.L. . Lam . Yun Wah . Steen . Hanno . Mann . Matthias . Lamond . Angus I. . 14132033 . free . 2002CBio...12....1A .
• Jäkel S . Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains . EMBO J. . 21 . 3 . 377–86 . 2002 . 11823430 . 10.1093/emboj/21.3.377 . 125346 . vanc. Mingot JM . Schwarzmaier P . 3 . Hartmann . E . Görlich . D .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M. free .
• Du JP . [Differential expression of RPL6/Taxreb107 in drug resistant gastric cancer cell line SGC7901/ADR and its correlation with multiple-drug resistance] . Zhonghua Zhong Liu Za Zhi . 25 . 1 . 21–5 . 2003 . 12678981 . vanc. Jin XH . Shi YQ . 3 . Cao . YX . Zhao . YQ . Liu . CJ . Yin . F . Hu . WH . Chen . BJ .
• Odintsova TI . Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing . J. Protein Chem. . 22 . 3 . 249–58 . 2004 . 12962325 . 10.1023/A:1025068419698 . vanc. Müller EC . Ivanov AV . 3 . Egorov . Tsezi A. . Bienert . Ralf . Vladimirov . Serguei N. . Kostka . Susanne . Otto . Albrecht . Wittmann-Liebold . Brigitte . 10710245 .
• Bouwmeester T . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway . Nat. Cell Biol. . 6 . 2 . 97–105 . 2004 . 14743216 . 10.1038/ncb1086 . vanc. Bauch A . Ruffner H . 3 . Angrand . Pierre-Olivier . Bergamini . Giovanna . Croughton . Karen . Cruciat . Cristina . Eberhard . Dirk . Gagneur . Julien . 11683986 .

Notes and References

1. Zaman GJ . Sequence of a cDNA encoding human ribosomal protein L26 and of a cDNA probably encoding human ribosomal protein L6 . Nucleic Acids Res . 21 . 7 . 1673 . May 1993 . 8479925 . 309386 . 10.1093/nar/21.7.1673 .
2. Morita T, Sato T, Nyunoya H, Tsujimoto A, Takahara J, Irino S, Shimotohno K . Isolation of a cDNA clone encoding DNA-binding protein (TAXREB107) that binds specifically to domain C of the tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I . AIDS Res Hum Retroviruses . 9 . 2 . 115–21 . Apr 1993 . 8457378 . 10.1089/aid.1993.9.115 .
3. Web site: Entrez Gene: RPL6 ribosomal protein L6.
4. Shen . B . Arese M . Gualandris A . Rifkin D B . Nov 1998 . Intracellular association of FGF-2 with the ribosomal protein L6/TAXREB107 . Biochem. Biophys. Res. Commun. . 252 . 2 . 524–8 . UNITED STATES. 0006-291X. 9826564 . 10.1006/bbrc.1998.9677 . free .