60S ribosomal protein L36a explained
60S ribosomal protein L36a is a protein that in humans is encoded by the RPL36A gene.[1] [2]
Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with yeast ribosomal protein L44, belongs to the L44E (L36AE) family of ribosomal proteins. Although this gene has been referred to as ribosomal protein L44 (RPL44), its official name is ribosomal protein L36a (RPL36A). This gene and the human gene officially named ribosomal protein L36a-like (RPL36AL) encode nearly identical proteins; however, they are distinct genes. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
Further reading
- Wool IG, Chan YL, Glück A . Structure and evolution of mammalian ribosomal proteins . Biochem. Cell Biol. . 73 . 11–12 . 933–47 . 1996 . 8722009 . 10.1139/o95-101 .
- Davies MS, Henney A, Ward WH, Craig RK . Characterisation of an mRNA encoding a human ribosomal protein homologous to the yeast L44 ribosomal protein . Gene . 45 . 2 . 183–91 . 1987 . 3542712 . 10.1016/0378-1119(86)90253-2 .
- Oeltjen JC . Sixty-nine kilobases of contiguous human genomic sequence containing the alpha-galactosidase A and Bruton's tyrosine kinase loci . Mamm. Genome . 6 . 5 . 334–8 . 1995 . 7626884 . 10.1007/BF00364796 . vanc. Liu X . Lu J . 3 . Allen . R. C. . Muzny . D. . Belmont . J. W. . Gibbs . R. A. . 22686077 .
- Kato S . Construction of a human full-length cDNA bank . Gene . 150 . 2 . 243–50 . 1995 . 7821789 . 10.1016/0378-1119(94)90433-2 . vanc. Sekine S . Oh SW . 3 . Nam-Soon . Kim . Yuri . Umezawa . Naoto . Abe . Midori . Yokoyama-Kobayashi . Takashi . Aoki .
- Vorechovský I . Isolation of cosmid and cDNA clones in the region surrounding the BTK gene at Xq21.3-q22 . Genomics . 21 . 3 . 517–24 . 1994 . 7959728 . 10.1006/geno.1994.1310 . vanc. Vetrie D . Holland J . 3 . Bentley . David R. . Thomas . Karen . Zhou . Jian-Nian . Notarangelo . Luigi D. . Plebani . Alessandro . Fontán . Gumorsindo .
- Cross SH, Charlton JA, Nan X, Bird AP . Purification of CpG islands using a methylated DNA binding column . Nat. Genet. . 6 . 3 . 236–44 . 1994 . 8012384 . 10.1038/ng0394-236 . 12847618 .
- Oeltjen JC . Large-scale comparative sequence analysis of the human and murine Bruton's tyrosine kinase loci reveals conserved regulatory domains . Genome Res. . 7 . 4 . 315–29 . 1997 . 9110171 . 10.1101/gr.7.4.315 . vanc. Malley TM . Muzny DM . 3 . Miller . W . Gibbs . RA . Belmont . JW . free.
- Gubin AN, Njoroge JM, Bouffard GG, Miller JL . Gene expression in proliferating human erythroid cells . Genomics . 59 . 2 . 168–77 . 1999 . 10409428 . 10.1006/geno.1999.5855 .
- Uechi T, Tanaka T, Kenmochi N . A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders . Genomics . 72 . 3 . 223–30 . 2001 . 11401437 . 10.1006/geno.2000.6470 .
- Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
- Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
- Kim JH . Over-expression of the ribosomal protein L36a gene is associated with cellular proliferation in hepatocellular carcinoma . Hepatology . 39 . 1 . 129–38 . 2004 . 14752831 . 10.1002/hep.20017 . vanc. You KR . Kim IH . 3 . Cho . Baik-Hwan . Kim . Chan-Young . Kim . Dae-Ghon . 36029858 . free.
- Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
- Ross MT . The DNA sequence of the human X chromosome . Nature . 434 . 7031 . 325–37 . 2005 . 15772651 . 10.1038/nature03440 . 2665286 . vanc. Grafham DV . Coffey AJ . 3 . Scherer . Steven . McLay . Kirsten . Muzny . Donna . Platzer . Matthias . Howell . Gareth R. . Burrows . Christine . 2005Natur.434..325R .
- Ewing RM . Large-scale mapping of human protein–protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . vanc. Chu P . Elisma F . 3 . Li . Hongyan . Taylor . Paul . Climie . Shane . McBroom-Cerajewski . Linda . Robinson . Mark D . O'Connor . Liam .
Notes and References
- Dixit VM, Hennessy SW, Grant GA, Rotwein P, Frazier WA . Characterization of a cDNA encoding the heparin and collagen binding domains of human thrombospondin . Proc Natl Acad Sci U S A . 83 . 15 . 5449–53 . Sep 1986 . 3461443 . 386304 . 10.1073/pnas.83.15.5449 . 1986PNAS...83.5449D . free .
- Web site: Entrez Gene: RPL36A ribosomal protein L36a.