60S ribosomal protein L35a explained

60S ribosomal protein L35a is a protein that in humans is encoded by the RPL35A gene.^{[1] [2] [3]}

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L35AE family of ribosomal proteins. It is located in the cytoplasm. The rat protein has been shown to bind to both initiator and elongator tRNAs, and thus, it is located at the P site, or P and A sites, of the ribosome. Although this gene was originally mapped to chromosome 18, it has been established that it is located at 3q29-qter. Transcript variants utilizing alternative transcription initiation sites and alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[3]

Further reading

• Wool IG, Chan YL, Glück A . Structure and evolution of mammalian ribosomal proteins. . Biochem. Cell Biol. . 73 . 11–12 . 933–47 . 1996 . 8722009 . 10.1139/o95-101 .
• Herzog H, Höfferer L, Schneider R, Schweiger M . cDNA encoding the human homologue of rat ribosomal protein L35a . Nucleic Acids Res. . 18 . 15 . 4600 . 1990 . 2388839 . 10.1093/nar/18.15.4600 . 331293 .
• Kato S, Sekine S, Oh SW, etal . Construction of a human full-length cDNA bank . Gene . 150 . 2 . 243–50 . 1995 . 7821789 . 10.1016/0378-1119(94)90433-2 .
• Kenmochi N, Kawaguchi T, Rozen S, etal . A map of 75 human ribosomal protein genes . Genome Res. . 8 . 5 . 509–23 . 1998 . 9582194 . 10.1101/gr.8.5.509. free .
• Kroes RA, Jastrow A, McLone MG, etal . The identification of novel therapeutic targets for the treatment of malignant brain tumors . Cancer Lett. . 156 . 2 . 191–8 . 2000 . 10880769 . 10.1016/S0304-3835(00)00462-6 .
• Yoshihama M, Uechi T, Asakawa S, etal . The human ribosomal protein genes: sequencing and comparative analysis of 73 genes . Genome Res. . 12 . 3 . 379–90 . 2002 . 11875025 . 10.1101/gr.214202 . 155282 .
• Lopez CD, Martinovsky G, Naumovski L . Inhibition of cell death by ribosomal protein L35a . Cancer Lett. . 180 . 2 . 195–202 . 2002 . 12175552 . 10.1016/S0304-3835(02)00024-1 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Kasai H, Nadano D, Hidaka E, etal . Differential expression of ribosomal proteins in human normal and neoplastic colorectum . J. Histochem. Cytochem. . 51 . 5 . 567–74 . 2003 . 12704204 . 10.1177/002215540305100502. 25865715 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Andersen JS, Lam YW, Leung AK, etal . Nucleolar proteome dynamics . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .

External links

• GeneReviews/NCBI/NIH/UW entry on Diamond-Blackfan Anemia

Notes and References

1. Feo S, Davies B, Fried M . The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome . Genomics . 13 . 1 . 201–7 . Jun 1992 . 1577483 . 10.1016/0888-7543(92)90221-D .
2. Colombo P, Read M, Fried M . The human L35a ribosomal protein (RPL35A) gene is located at chromosome band 3q29-qter . Genomics . 32 . 1 . 148–50 . Sep 1996 . 8786106 . 10.1006/geno.1996.0093 .
3. Web site: Entrez Gene: RPL35A ribosomal protein L35a.