60S ribosomal protein L27a explained

60S ribosomal protein L27a is a protein that in humans is encoded by the RPL27A gene.^{[1] [2] [3]}

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L15P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, multiple processed pseudogenes derived from this gene are dispersed through the genome.^[3]

Further reading

• Wool IG, Chan YL, Glück A . Structure and evolution of mammalian ribosomal proteins . Biochem. Cell Biol. . 73 . 11–12 . 933–947 . 1996 . 8722009 . 10.1139/o95-101 .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–45 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Andersen JS . Directed proteomic analysis of the human nucleolus . Curr. Biol. . 12 . 1 . 1–11 . 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9 . vanc. Lyon CE . Fox AH . 3 . Leung . Anthony K.L. . Lam . Yun Wah . Steen . Hanno . Mann . Matthias . Lamond . Angus I. . 14132033 . free . 2002CBio...12....1A .
• Bortoluzzi S, d'Alessi F, Romualdi C, Danieli GA . Differential expression of genes coding for ribosomal proteins in different human tissues . Bioinformatics . 17 . 12 . 1152–1157 . 2002 . 11751223 . 10.1093/bioinformatics/17.12.1152 . free .
• Kusuda J . Genomic structure and chromosome location of RPL27A/Rpl27a, the genes encoding human and mouse ribosomal protein L27A . Cytogenet. Cell Genet. . 85 . 3–4 . 248–251 . 1999 . 10449908 . 10.1159/000015303 . vanc. Hirai M . Tanuma R . 3 . Hirata . M. . Hashimoto . K. . 7314458 .

Notes and References

1. Frigerio JM, Dagorn JC, Iovanna JL . Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs . Biochim Biophys Acta . 1262 . 1 . 64–8 . Jul 1995 . 7772601 . 10.1016/0167-4781(95)00045-i.
2. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC . A map of 75 human ribosomal protein genes . Genome Res . 8 . 5 . 509–23 . Aug 1998 . 9582194 . 10.1101/gr.8.5.509. free .
3. Web site: Entrez Gene: RPL27A ribosomal protein L27a.