60S ribosomal protein L27 explained

60S ribosomal protein L27 is a protein that in humans is encoded by the RPL27 gene.^{[1] [2]}

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L27E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[3]

Further reading

• Wool IG, Chan YL, Glück A . Structure and evolution of mammalian ribosomal proteins. . Biochem. Cell Biol. . 73 . 11–12 . 933–47 . 1996 . 8722009 . 10.1139/o95-101 .
• Miki Y, Swensen J, Shattuck-Eidens D, etal . A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. . Science . 266 . 5182 . 66–71 . 1994 . 7545954 . 10.1126/science.7545954 . 1994Sci...266...66M . free .
• Harshman K, Bell R, Rosenthal J, etal . Comparison of the positional cloning methods used to isolate the BRCA1 gene. . Hum. Mol. Genet. . 4 . 8 . 1259–66 . 1995 . 7581362 . 10.1093/hmg/4.8.1259 .
• Gallagher RA, McClean PM, Malik AN . Cloning and nucleotide sequence of a full length cDNA encoding ribosomal protein L27 from human fetal kidney. . Biochim. Biophys. Acta . 1217 . 3 . 329–32 . 1994 . 8148381 . 10.1016/0167-4781(94)90295-x.
• Uechi T, Tanaka T, Kenmochi N . A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders. . Genomics . 72 . 3 . 223–30 . 2001 . 11401437 . 10.1006/geno.2000.6470 .
• Andersen JS, Lyon CE, Fox AH, etal . Directed proteomic analysis of the human nucleolus. . Curr. Biol. . 12 . 1 . 1–11 . 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9 . 14132033 . free . 2002CBio...12....1A .
• Yoshihama M, Uechi T, Asakawa S, etal . The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. . Genome Res. . 12 . 3 . 379–90 . 2002 . 11875025 . 10.1101/gr.214202 . 155282 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Andersen JS, Lam YW, Leung AK, etal . Nucleolar proteome dynamics. . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 .

Notes and References

1. Jones KW, Chevrette M, Shapero MH, Fournier RE . Generation of region- and species-specific expressed gene probes from somatic cell hybrids . Nat Genet . 1 . 4 . 278–83 . Jun 1993 . 1302024 . 10.1038/ng0792-278 . 30900271 .
2. Web site: Entrez Gene: RPL27 ribosomal protein L27.
3. Web site: Entrez Gene: RPL27 ribosomal protein L27.