60S ribosomal protein L19 explained

Large ribosomal subunit protein eL19 is a protein that in humans is encoded by the RPL19 gene.^{[1] [2]}

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L19E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[3]

Pseudogenes

There are 21 pseudogenes:RPL19P1,^[4] RPL19P2,^[5] RPL19P3,^[6] RPL19P4,^[7] RPL19P5,^[8] RPL19P6,^[9] RPL19P7,^[10] RPL19P8,^[11] RPL19P9,^[12] RPL19P10,^[13] RPL19P11,^[14] RPL19P12,^[15] RPL19P13,^[16] RPL19P14,^[17] RPL19P15,^[18] RPL19P16,^[19] RPL19P17,^[20] RPL19P18,^[21] RPL19P19,^[22] RPL19P20,^[23] andRPL19P21.^[24]

Further reading

• Wool IG, Chan YL, Glück A . Structure and evolution of mammalian ribosomal proteins. . Biochem. Cell Biol. . 73 . 11–12 . 933–47 . 1996 . 8722009 . 10.1139/o95-101 .
• Kumabe T, Sohma Y, Yamamoto T . Human cDNAs encoding elongation factor 1 gamma and the ribosomal protein L19. . Nucleic Acids Res. . 20 . 10 . 2598 . 1992 . 1598220 . 10.1093/nar/20.10.2598 . 312399 .
• Chan YL, Lin A, McNally J, etal . The primary structure of rat ribosomal protein L19. A determination from the sequence of nucleotides in a cDNA and from the sequence of amino acids in the protein. . J. Biol. Chem. . 262 . 3 . 1111–5 . 1987 . 10.1016/S0021-9258(19)75757-3 . 3542997 . free .
• Davies B, Fried M . The L19 ribosomal protein gene (RPL19): gene organization, chromosomal mapping, and novel promoter region. . Genomics . 25 . 2 . 372–80 . 1995 . 7789970 . 10.1016/0888-7543(95)80036-L .
• Henry JL, Coggin DL, King CR . High-level expression of the ribosomal protein L19 in human breast tumors that overexpress erbB-2. . Cancer Res. . 53 . 6 . 1403–8 . 1993 . 8095182 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Uechi T, Tanaka T, Kenmochi N . A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders. . Genomics . 72 . 3 . 223–30 . 2001 . 11401437 . 10.1006/geno.2000.6470 .
• Deprez PH, Sempoux C, De Saeger C, etal . Expression of cholecystokinin in the duodenum of patients with coeliac disease: respective role of atrophy and lymphocytic infiltration. . Clin. Sci. . 103 . 2 . 171–7 . 2002 . 12149109 . 10.1042/CS20020033 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Bee A, Ke Y, Forootan S, etal . Ribosomal protein l19 is a prognostic marker for human prostate cancer. . Clin. Cancer Res. . 12 . 7 Pt 1 . 2061–5 . 2006 . 16609016 . 10.1158/1078-0432.CCR-05-2445 . 7231453 .
• Lederer CW, Torrisi A, Pantelidou M, etal . Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis. . BMC Genomics . 8 . 26 . 2007 . 17244347 . 10.1186/1471-2164-8-26 . 1796866 . free .

Notes and References

1. Feo S, Davies B, Fried M . The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome . Genomics . 13 . 1 . 201–7 . Jun 1992 . 1577483 . 10.1016/0888-7543(92)90221-D .
2. Web site: RPL19 ribosomal protein L19 [Homo sapiens (human) ]].
3. Web site: Entrez Gene: RPL19 ribosomal protein L19.
4. Web site: Symbol report for RPL19P1. HUGO Gene Nomenclature Committee (HGNC).
5. Web site: Symbol report for RPL19P2. HUGO Gene Nomenclature Committee (HGNC).
6. Web site: Symbol report for RPL19P3. HUGO Gene Nomenclature Committee (HGNC).
7. Web site: Symbol report for RPL19P4. HUGO Gene Nomenclature Committee (HGNC).
8. Web site: Symbol report for RPL19P5. HUGO Gene Nomenclature Committee (HGNC).
9. Web site: Symbol report for RPL19P6. HUGO Gene Nomenclature Committee (HGNC).
10. Web site: Symbol report for RPL19P7. HUGO Gene Nomenclature Committee (HGNC).
11. Web site: Symbol report for RPL19P8. HUGO Gene Nomenclature Committee (HGNC).
12. Web site: Symbol report for RPL19P9. HUGO Gene Nomenclature Committee (HGNC).
13. Web site: Symbol report for RPL19P10. HUGO Gene Nomenclature Committee (HGNC).
14. Web site: Symbol report for RPL19P11. HUGO Gene Nomenclature Committee (HGNC).
15. Web site: Symbol report for RPL19P12. HUGO Gene Nomenclature Committee (HGNC).
16. Web site: Symbol report for RPL19P13. HUGO Gene Nomenclature Committee (HGNC).
17. Web site: Symbol report for RPL19P14. HUGO Gene Nomenclature Committee (HGNC).
18. Web site: Symbol report for RPL19P15. HUGO Gene Nomenclature Committee (HGNC).
19. Web site: Symbol report for RPL19P16. HUGO Gene Nomenclature Committee (HGNC).
20. Web site: Symbol report for RPL19P17. HUGO Gene Nomenclature Committee (HGNC).
21. Web site: Symbol report for RPL19P18. HUGO Gene Nomenclature Committee (HGNC).
22. Web site: Symbol report for RPL19P19. HUGO Gene Nomenclature Committee (HGNC).
23. Web site: Symbol report for RPL19P20. HUGO Gene Nomenclature Committee (HGNC).
24. Web site: Symbol report for RPL19P21. HUGO Gene Nomenclature Committee (HGNC).