60S ribosomal protein L10a explained

60S ribosomal protein L10a is a protein that in humans is encoded by the RPL10A gene.^{[1] [2] [3]}

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L1P family of ribosomal proteins. It is located in the cytoplasm. The expression of this gene is downregulated in the thymus by cyclosporin-A (CsA), an immunosuppressive drug. Studies in mice have shown that the expression of the ribosomal protein L10a gene is downregulated in neural precursor cells during development. This gene used to be referred to as NEDD6 (neural precursor cell expressed, developmentally downregulated 6), but it has been renamed RPL10A (ribosomal protein 10a). As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[3]

Further reading

• Wool IG, Chan YL, Glück A . Structure and evolution of mammalian ribosomal proteins. . Biochem. Cell Biol. . 73 . 11–12 . 933–47 . 1996 . 8722009 . 10.1139/o95-101 .
• Cross SH, Charlton JA, Nan X, Bird AP . Purification of CpG islands using a methylated DNA binding column. . Nat. Genet. . 6 . 3 . 236–44 . 1994 . 8012384 . 10.1038/ng0394-236 . 12847618 .
• Olvera J, Wool IG . The primary structure of rat ribosomal protein L10a. . Biochem. Biophys. Res. Commun. . 220 . 3 . 954–7 . 1996 . 8607874 . 10.1006/bbrc.1996.0513 .
• Kenmochi N, Kawaguchi T, Rozen S, etal . A map of 75 human ribosomal protein genes. . Genome Res. . 8 . 5 . 509–23 . 1998 . 9582194 . 10.1101/gr.8.5.509. free .
• Andersen JS, Lyon CE, Fox AH, etal . Directed proteomic analysis of the human nucleolus. . Curr. Biol. . 12 . 1 . 1–11 . 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9 . 14132033 . free . 2002CBio...12....1A .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Koga M, Shichijo S, Yamada A, etal . Identification of ribosomal proteins S2 and L10a as tumor antigens recognized by HLA-A26-restricted CTL. . Tissue Antigens . 61 . 2 . 136–45 . 2004 . 12694581 . 10.1046/j.0001-2815.2002.00009.x .
• Odintsova TI, Müller EC, Ivanov AV, etal . Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. . J. Protein Chem. . 22 . 3 . 249–58 . 2004 . 12962325 . 10.1023/A:1025068419698 . 10710245 .
• Mungall AJ, Palmer SA, Sims SK, etal . The DNA sequence and analysis of human chromosome 6. . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . free .
• Bouwmeester T, Bauch A, Ruffner H, etal . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. . Nat. Cell Biol. . 6 . 2 . 97–105 . 2004 . 14743216 . 10.1038/ncb1086 . 11683986 .
• Suzuki Y, Yamashita R, Shirota M, etal . Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. . Genome Res. . 14 . 9 . 1711–8 . 2004 . 15342556 . 10.1101/gr.2435604 . 515316 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Andersen JS, Lam YW, Leung AK, etal . Nucleolar proteome dynamics. . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 .

Notes and References

1. Fisicaro N, Katerelos M, Williams J, Power D, D'Apice A, Pearse M . Identification of genes downregulated in the thymus by cyclosporin-A: preliminary characterization of clone CSA-19 . Mol Immunol . 32 . 8 . 565–72 . Aug 1995 . 7609734 . 10.1016/0161-5890(95)00032-A .
2. Tripodis N, Mason R, Humphray SJ, Davies AF, Herberg JA, Trowsdale J, Nizetic D, Senger G, Ragoussis J . Physical map of human 6p21.2-6p21.3: region flanking the centromeric end of the major histocompatibility complex . Genome Res . 8 . 6 . 631–43 . Jan 1999 . 9647638 . 310739 . 10.1101/gr.8.6.631.
3. Web site: Entrez Gene: RPL10A ribosomal protein L10a.