RPH3AL explained

Rab effector Noc2 is a protein that in humans is encoded by the RPH3AL gene.^{[1] [2]}

Interactions

RPH3AL has been shown to interact with RAB27A.^{[3] [4]}

Further reading

• Kotake K, Ozaki N, Mizuta M, Sekiya S, Inagaki N, Seino S . Noc2, a putative zinc finger protein involved in exocytosis in endocrine cells . The Journal of Biological Chemistry . 272 . 47 . 29407–10 . November 1997 . 9367993 . 10.1074/jbc.272.47.29407 . free .
• Fenster SD, Chung WJ, Zhai R, Cases-Langhoff C, Voss B, Garner AM, Kaempf U, Kindler S, Gundelfinger ED, Garner CC . Piccolo, a presynaptic zinc finger protein structurally related to bassoon . Neuron . 25 . 1 . 203–14 . January 2000 . 10707984 . 10.1016/S0896-6273(00)80883-1 . 10177138 . free .
• Haynes LP, Evans GJ, Morgan A, Burgoyne RD . A direct inhibitory role for the Rab3-specific effector, Noc2, in Ca2+-regulated exocytosis in neuroendocrine cells . The Journal of Biological Chemistry . 276 . 13 . 9726–32 . March 2001 . 11134008 . 10.1074/jbc.M006959200 . free .
• Goi T, Takeuchi K, Katayama K, Hirose K, Yamaguchi A . Mutations of rabphillin-3A-like gene in colorectal cancers . Oncology Reports . 9 . 6 . 1189–92 . 2003 . 12375017 . 10.3892/or.9.6.1189 .
• Milkereit P, Strauss D, Bassler J, Gadal O, Kühn H, Schütz S, Gas N, Lechner J, Hurt E, Tschochner H . A Noc complex specifically involved in the formation and nuclear export of ribosomal 40 S subunits . The Journal of Biological Chemistry . 278 . 6 . 4072–81 . February 2003 . 12446671 . 10.1074/jbc.M208898200 . free .
• Fukuda M . Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2 . The Journal of Biological Chemistry . 278 . 17 . 15373–80 . April 2003 . 12578829 . 10.1074/jbc.M212341200 . free .
• Cardoso C, Leventer RJ, Ward HL, Toyo-Oka K, Chung J, Gross A, Martin CL, Allanson J, Pilz DT, Olney AH, Mutchinick OM, Hirotsune S, Wynshaw-Boris A, Dobyns WB, Ledbetter DH . Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3 . American Journal of Human Genetics . 72 . 4 . 918–30 . April 2003 . 12621583 . 1180354 . 10.1086/374320 .
• Cheviet S, Coppola T, Haynes LP, Burgoyne RD, Regazzi R . The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis . Molecular Endocrinology . 18 . 1 . 117–26 . January 2004 . 14593078 . 10.1210/me.2003-0300 . free .
• Manabe S, Nishimura N, Yamamoto Y, Kitamura H, Morimoto S, Imai M, Nagahiro S, Seino S, Sasaki T . Identification and characterization of Noc2 as a potential Rab3B effector protein in epithelial cells . Biochemical and Biophysical Research Communications . 316 . 1 . 218–25 . March 2004 . 15003533 . 10.1016/j.bbrc.2004.02.026 .
• Matsumoto M, Miki T, Shibasaki T, Kawaguchi M, Shinozaki H, Nio J, Saraya A, Koseki H, Miyazaki M, Iwanaga T, Seino S . Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells . Proceedings of the National Academy of Sciences of the United States of America . 101 . 22 . 8313–8 . June 2004 . 15159548 . 420391 . 10.1073/pnas.0306709101 . 2004PNAS..101.8313M . free .
• Katkoori VR, Jia X, Chatla C, Kumar S, Ponnazhagan S, Callens T, Messiaen L, Grizzle WE, Manne U . Clinical significance of a novel single nucleotide polymorphism in the 5' untranslated region of the Rabphillin-3A-Like gene in colorectal adenocarcinoma . Frontiers in Bioscience . 13 . 1 . 1050–61 . January 2008 . 17981610 . 2667692 . 10.2741/2742 .

Notes and References

1. Smith JS, Tachibana I, Allen C, Chiappa SA, Lee HK, McIver B, Jenkins RB, Raffel C . Cloning of a human ortholog (RPH3AL) of (RNO)Rph3al from a candidate 17p13.3 medulloblastoma tumor suppressor locus . Genomics . 59 . 1 . 97–101 . July 1999 . 10395805 . 10.1006/geno.1999.5864 .
2. Web site: Entrez Gene: RPH3AL rabphilin 3A-like (without C2 domains).
3. Cheviet S, Coppola T, Haynes LP, Burgoyne RD, Regazzi R . The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis . Molecular Endocrinology . 18 . 1 . 117–26 . January 2004 . 14593078 . 10.1210/me.2003-0300 . free .
4. Fukuda M . Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2 . The Journal of Biological Chemistry . 278 . 17 . 15373–80 . April 2003 . 12578829 . 10.1074/jbc.M212341200 . free .