Replication protein A3 explained

Replication protein A 14 kDa subunit is a protein that in humans is encoded by the RPA3 gene.^{[1] [2]}

Interactions

RPA3 has been shown to interact with replication protein A1^{[3] [4]} and replication protein A2.^{[3] [4]}

See also

• Single-stranded binding protein
• Replication protein A
• Replication protein A1
• Replication protein A2

Further reading

• Iftode C, Daniely Y, Borowiec JA . Replication protein A (RPA): the eukaryotic SSB . Critical Reviews in Biochemistry and Molecular Biology . 34 . 3 . 141–80 . 1999 . 10473346 . 10.1080/10409239991209255 .
• Keshav KF, Chen C, Dutta A . Rpa4, a homolog of the 34-kilodalton subunit of the replication protein A complex . Molecular and Cellular Biology . 15 . 6 . 3119–28 . Jun 1995 . 7760808 . 230543 . 10.1128/mcb.15.6.3119.
• Umbricht CB, Griffin CA, Hawkins AL, Grzeschik KH, O'Connell P, Leach R, Green ED, Kelly TJ . High-resolution genomic mapping of the three human replication protein A genes (RPA1, RPA2, and RPA3) . Genomics . 20 . 2 . 249–57 . Mar 1994 . 8020972 . 10.1006/geno.1994.1161 . free .
• Amacker M, Hottiger M, Mossi R, Hübscher U . HIV-1 nucleocapsid protein and replication protein A influence the strand displacement DNA synthesis of lentiviral reverse transcriptase . AIDS . 11 . 4 . 534–6 . Mar 1997 . 9084803 .
• Bochkareva E, Frappier L, Edwards AM, Bochkarev A . The RPA32 subunit of human replication protein A contains a single-stranded DNA-binding domain . The Journal of Biological Chemistry . 273 . 7 . 3932–6 . Feb 1998 . 9461578 . 10.1074/jbc.273.7.3932 . free .
• Toward a complete human genome sequence . Genome Research . 8 . 11 . 1097–108 . Nov 1998 . 9847074 . 10.1101/gr.8.11.1097 . Sanger Centre . The . Washington University Genome Sequencing Cente . The . free .
• Mer G, Bochkarev A, Gupta R, Bochkareva E, Frappier L, Ingles CJ, Edwards AM, Chazin WJ . Structural basis for the recognition of DNA repair proteins UNG2, XPA, and RAD52 by replication factor RPA . Cell . 103 . 3 . 449–56 . Oct 2000 . 11081631 . 10.1016/S0092-8674(00)00136-7 . 16640087 . free .
• Habel JE, Ohren JF, Borgstahl GE . Dynamic light-scattering analysis of full-length human RPA14/32 dimer: purification, crystallization and self-association . Acta Crystallographica Section D . 57 . Pt 2 . 254–9 . Feb 2001 . 11173472 . 10.1107/S0907444900015225 .
• Bochkareva E, Korolev S, Lees-Miller SP, Bochkarev A . Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA . The EMBO Journal . 21 . 7 . 1855–63 . Apr 2002 . 11927569 . 125950 . 10.1093/emboj/21.7.1855 .
• Kneissl M, Pütter V, Szalay AA, Grummt F . Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells . Journal of Molecular Biology . 327 . 1 . 111–28 . Mar 2003 . 12614612 . 10.1016/S0022-2836(03)00079-2 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .
• Sankaranarayanan P, Schomay TE, Aiello KA, Alter O . Tensor GSVD of patient- and platform-matched tumor and normal DNA copy-number profiles uncovers chromosome arm-wide patterns of tumor-exclusive platform-consistent alterations encoding for cell transformation and predicting ovarian cancer survival . PLOS ONE . 10 . 4 . e0121396 . April 2015 . 25875127 . 10.1371/journal.pone.0121396 . AAAS EurekAlert! Press Release and NAE Podcast Feature . 4398562. 2015PLoSO..1021396S . free .

Notes and References

1. Umbricht CB, Erdile LF, Jabs EW, Kelly TJ . Cloning, overexpression, and genomic mapping of the 14-kDa subunit of human replication protein A . . 268 . 9 . 6131–8 . Mar 1993 . 10.1016/S0021-9258(18)53229-4 . 8454588 . free .
2. Web site: Entrez Gene: RPA3 replication protein A3, 14kDa.
3. Bochkareva E, Frappier L, Edwards AM, Bochkarev A . The RPA32 subunit of human replication protein A contains a single-stranded DNA-binding domain . . 273 . 7 . 3932–6 . Feb 1998 . 9461578 . 10.1074/jbc.273.7.3932 . free .
4. Bochkareva E, Korolev S, Lees-Miller SP, Bochkarev A . Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA . . 21 . 7 . 1855–63 . Apr 2002 . 11927569 . 125950 . 10.1093/emboj/21.7.1855 .