MST4 explained

Serine/threonine protein kinase MST4, also known as mammalian STE20-like protein kinase 4 (MST-4), is a protein that in humans is encoded by the MST4 gene.^[1]

Function

The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Interactions

RP6-213H19.1 has been shown to interact with:

• CTTNBP2NL,
• CTTNBP2,
• FAM40A,
• MOBKL3,
• PDCD10,
• STRN3, and
• STRN.^[2]

Further reading

• Liu KC, Wang D . [Synthesis of n-substituted beta-methyl DL-aspartates as potential hypocholesteremics (author's transl)] . Archiv der Pharmazie . 308 . 7 . 564–70 . 1975 . 1164178 . 10.1002/ardp.19753080712. 82913379 .
• Qian Z, Lin C, Espinosa R, LeBeau M, Rosner MR . Cloning and characterization of MST4, a novel Ste20-like kinase . J. Biol. Chem. . 276 . 25 . 22439–45 . 2001 . 11306563 . 10.1074/jbc.M009323200 . free .
• Dan I, Watanabe NM, Kusumi A . The Ste20 group kinases as regulators of MAP kinase cascades . Trends Cell Biol. . 11 . 5 . 220–30 . 2001 . 11316611 . 10.1016/S0962-8924(01)01980-8 .
• Lin JL, Chen HC, Fang HI, Robinson D, Kung HJ, Shih HM . MST4, a new Ste20-related kinase that mediates cell growth and transformation via modulating ERK pathway . Oncogene . 20 . 45 . 6559–69 . 2001 . 11641781 . 10.1038/sj.onc.1204818 . 27885152 .
• Dan I, Ong SE, Watanabe NM, Blagoev B, Nielsen MM, Kajikawa E, Kristiansen TZ, Mann M, Pandey A . Cloning of MASK, a novel member of the mammalian germinal center kinase III subfamily, with apoptosis-inducing properties . J. Biol. Chem. . 277 . 8 . 5929–39 . 2002 . 11741893 . 10.1074/jbc.M110882200 . free .
• Sung V, Luo W, Qian D, Lee I, Jallal B, Gishizky M . The Ste20 kinase MST4 plays a role in prostate cancer progression . Cancer Res. . 63 . 12 . 3356–63 . 2003 . 12810671 .
• Preisinger C, Short B, De Corte V, Bruyneel E, Haas A, Kopajtich R, Gettemans J, Barr FA . YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta . J. Cell Biol. . 164 . 7 . 1009–20 . 2004 . 15037601 . 2172068 . 10.1083/jcb.200310061 .
• Chan EH, Nousiainen M, Chalamalasetty RB, Schäfer A, Nigg EA, Silljé HH . The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1 . Oncogene . 24 . 12 . 2076–86 . 2005 . 15688006 . 10.1038/sj.onc.1208445 . 27285160 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
• Ma X, Zhao H, Shan J, Long F, Chen Y, Chen Y, Zhang Y, Han X, Ma D . PDCD10 interacts with Ste20-related kinase MST4 to promote cell growth and transformation via modulation of the ERK pathway . Mol. Biol. Cell . 18 . 6 . 1965–78 . 2007 . 17360971 . 1877091 . 10.1091/mbc.E06-07-0608 .

Notes and References

1. Web site: Entrez Gene: RP6-213H19.1 serine/threonine protein kinase MST4.
2. Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC . A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein . Mol. Cell. Proteomics . 8 . 1 . 157–71 . January 2009 . 18782753 . 2621004 . 10.1074/mcp.M800266-MCP200 . free .