ROBO4 explained
Roundabout homolog 4 is a protein that in humans is encoded by the ROBO4 gene.[1] [2]
Further reading
- Schmucker D . Downstream of guidance receptors: entering the baroque period of axon guidance signaling . Neuron . 40 . 1 . 4–6 . September 2003 . 14527427 . 10.1016/S0896-6273(03)00603-2 . 15871522 . free .
- Huminiecki L, Gorn M, Suchting S, Poulsom R, Bicknell R . Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis . Genomics . 79 . 4 . 547–52 . April 2002 . 11944987 . 10.1006/geno.2002.6745 .
- Park KW, Morrison CM, Sorensen LK, Jones CA, Rao Y, Chien CB, Wu JY, Urness LD, Li DY . Robo4 is a vascular-specific receptor that inhibits endothelial migration . Developmental Biology . 261 . 1 . 251–67 . September 2003 . 12941633 . 10.1016/S0012-1606(03)00258-6 . free .
- Bedell VM, Yeo SY, Park KW, Chung J, Seth P, Shivalingappa V, Zhao J, Obara T, Sukhatme VP, Drummond IA, Li DY, Ramchandran R . roundabout4 is essential for angiogenesis in vivo . Proceedings of the National Academy of Sciences of the United States of America . 102 . 18 . 6373–8 . May 2005 . 15849270 . 1088354 . 10.1073/pnas.0408318102 . 2005PNAS..102.6373B . free .
- Seth P, Lin Y, Hanai J, Shivalingappa V, Duyao MP, Sukhatme VP . Magic roundabout, a tumor endothelial marker: expression and signaling . Biochemical and Biophysical Research Communications . 332 . 2 . 533–41 . July 2005 . 15894287 . 10.1016/j.bbrc.2005.03.250 .
- Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD . Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry . Journal of Proteome Research . 4 . 6 . 2070–80 . 2006 . 16335952 . 1850943 . 10.1021/pr0502065 .
- Gröne J, Doebler O, Loddenkemper C, Hotz B, Buhr HJ, Bhargava S . Robo1/Robo4: differential expression of angiogenic markers in colorectal cancer . Oncology Reports . 15 . 6 . 1437–43 . June 2006 . 16685377 . 10.3892/or.15.6.1437 . free .
- Okada Y, Yano K, Jin E, Funahashi N, Kitayama M, Doi T, Spokes K, Beeler DL, Shih SC, Okada H, Danilov TA, Maynard E, Minami T, Oettgen P, Aird WC . A three-kilobase fragment of the human Robo4 promoter directs cell type-specific expression in endothelium . Circulation Research . 100 . 12 . 1712–22 . June 2007 . 17495228 . 10.1161/01.RES.0000269779.10644.dc . free .
Notes and References
- Huminiecki L, Bicknell R . In silico cloning of novel endothelial-specific genes . Genome Research . 10 . 11 . 1796–806 . November 2000 . 11076864 . 310981 . 10.1101/gr.150700 .
- Web site: Entrez Gene: ROBO4 roundabout homolog 4, magic roundabout (Drosophila).