ROBO2 explained

Roundabout homolog 2 is a protein that in humans is encoded by the ROBO2 gene.^{[1] [2]}

Further reading

• Hauptman G, Reichert MC, Abdal Rhida MA, Evans TA . Characterization of enhancer fragments in Drosophila robo2 . Fly . 16 . 1 . 312–346 . December 2022 . 36217698 . 9559326 . 10.1080/19336934.2022.2126259 .
• Brose K, Bland KS, Wang KH, Arnott D, Henzel W, Goodman CS, Tessier-Lavigne M, Kidd T . 6 . Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance . Cell . 96 . 6 . 795–806 . March 1999 . 10102268 . 10.1016/S0092-8674(00)80590-5 . 16301178 . free .
• Nguyen Ba-Charvet KT, Brose K, Marillat V, Kidd T, Goodman CS, Tessier-Lavigne M, Sotelo C, Chédotal A . 6 . Slit2-Mediated chemorepulsion and collapse of developing forebrain axons . Neuron . 22 . 3 . 463–473 . March 1999 . 10197527 . 10.1016/S0896-6273(00)80702-3 . 18663762 . free .
• Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O . Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Research . 7 . 4 . 273–281 . August 2000 . 10997877 . 10.1093/dnares/7.4.271 . free .
• Nguyen Ba-Charvet KT, Brose K, Ma L, Wang KH, Marillat V, Sotelo C, Tessier-Lavigne M, Chédotal A . 6 . Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance . The Journal of Neuroscience . 21 . 12 . 4281–4289 . June 2001 . 11404413 . 6762758 . 10.1523/JNEUROSCI.21-12-04281.2001 . free .
• Marillat V, Cases O, Nguyen-Ba-Charvet KT, Tessier-Lavigne M, Sotelo C, Chédotal A . Spatiotemporal expression patterns of slit and robo genes in the rat brain . The Journal of Comparative Neurology . 442 . 2 . 130–155 . January 2002 . 11754167 . 10.1002/cne.10068 . 24164570 .
• Hivert B, Liu Z, Chuang CY, Doherty P, Sundaresan V . Robo1 and Robo2 are homophilic binding molecules that promote axonal growth . Molecular and Cellular Neurosciences . 21 . 4 . 534–545 . December 2002 . 12504588 . 10.1006/mcne.2002.1193 . 19664833 .
• Grieshammer U, Plump AS, Wang F, Tessier-Lavigne M, Martin GR . SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site . Developmental Cell . 6 . 5 . 709–717 . May 2004 . 15130495 . 10.1016/S1534-5807(04)00108-X . free .
• Yue Y, Grossmann B, Galetzka D, Zechner U, Haaf T . Isolation and differential expression of two isoforms of the ROBO2/Robo2 axon guidance receptor gene in humans and mice . Genomics . 88 . 6 . 772–778 . December 2006 . 16829019 . 10.1016/j.ygeno.2006.05.011 . free .
• Lu W, van Eerde AM, Fan X, Quintero-Rivera F, Kulkarni S, Ferguson H, Kim HG, Fan Y, Xi Q, Li QG, Sanlaville D, Andrews W, Sundaresan V, Bi W, Yan J, Giltay JC, Wijmenga C, de Jong TP, Feather SA, Woolf AS, Rao Y, Lupski JR, Eccles MR, Quade BJ, Gusella JF, Morton CC, Maas RL . 6 . Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux . American Journal of Human Genetics . 80 . 4 . 616–632 . April 2007 . 17357069 . 1852714 . 10.1086/512735 .

Notes and References

1. Kidd T, Brose K, Mitchell KJ, Fetter RD, Tessier-Lavigne M, Goodman CS, Tear G . Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors . Cell . 92 . 2 . 205–215 . January 1998 . 9458045 . 10.1016/S0092-8674(00)80915-0 . 2036419 . free .
2. Web site: Entrez Gene: ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila).