Ribonuclease U2 Explained

Ribonuclease U2
Ec Number:	3.1.27.4
Cas Number:	37205-57-5

Ribonuclease U2 (purine specific endoribonuclease, ribonuclease U3, RNase U3, RNase U2, purine-specific ribonuclease, purine-specific RNase, Pleospora RNase, Trichoderma koningi RNase III, ribonuclease (purine)) is an enzyme.^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

Two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Ap or Gp with 2',3'-cyclic phosphate intermediates

Notes and References

1. Glitz DG, Dekker CA . Studies on a ribonuclease from Ustilago sphaerogena. I. Purification and properties of the enzyme . Biochemistry . 3 . 10 . 1391–9 . October 1964 . 14230791 . 10.1021/bi00898a001 .
2. Glitz DG, Dekker CA . Studies on a ribonuclease from Ustilago sphaerogena. II. Specificity of the enzyme . Biochemistry . 3 . 10 . 1399–406 . October 1964 . 14230792 . 10.1021/bi00898a002 .
3. Book: The Enzymes . Uchida T, Egami F . Microbial ribonucleases with special reference to RNases T1, T 2, N 1, and U2. 1971 . 4 . 205–250 . Boyer PD . 3rd . Academic Press . New York .