RNH1 explained

Ribonuclease inhibitor is an enzyme that in humans is encoded by the RNH1 gene.^[1]

Further reading

• Zneimer SM, Crawford D, Schneider NR, Beutler B . Mapping of the human ribonuclease inhibitor gene (RNH) to chromosome 11p15 by in situ hybridization. . Genomics . 8 . 1 . 175–8 . 1991 . 2081593 . 10.1016/0888-7543(90)90242-M .
• Weremowicz S, Fox EA, Morton CC, Vallee BL . The placental ribonuclease inhibitor (RNH) gene is located on chromosome subband 11p15.5. . Genomics . 8 . 4 . 717–21 . 1991 . 2276743 . 10.1016/0888-7543(90)90260-2 .
• Lee FS, Vallee BL . Binding of placental ribonuclease inhibitor to the active site of angiogenin. . Biochemistry . 28 . 8 . 3556–61 . 1989 . 2742853 . 10.1021/bi00434a061 .
• Bond MD, Vallee BL . Isolation of bovine angiogenin using a placental ribonuclease inhibitor binding assay. . Biochemistry . 27 . 17 . 6282–7 . 1989 . 3064806 . 10.1021/bi00417a013 .
• Hofsteenge J, Kieffer B, Matthies R, etal . Amino acid sequence of the ribonuclease inhibitor from porcine liver reveals the presence of leucine-rich repeats. . Biochemistry . 27 . 23 . 8537–44 . 1989 . 3219361 . 10.1021/bi00423a006 .
• Lee FS, Fox EA, Zhou HM, etal . Primary structure of human placental ribonuclease inhibitor. . Biochemistry . 27 . 23 . 8545–53 . 1989 . 3219362 . 10.1021/bi00423a007 .
• Schneider R, Schneider-Scherzer E, Thurnher M, etal . The primary structure of human ribonuclease/angiogenin inhibitor (RAI) discloses a novel highly diversified protein superfamily with a common repetitive module . EMBO J. . 7 . 13 . 4151–6 . 1989 . 3243277 . 10.1002/j.1460-2075.1988.tb03310.x. 455125 .
• Shapiro R, Vallee BL . Human placental ribonuclease inhibitor abolishes both angiogenic and ribonucleolytic activities of angiogenin . Proc. Natl. Acad. Sci. U.S.A. . 84 . 8 . 2238–41 . 1987 . 3470787 . 10.1073/pnas.84.8.2238 . 304624 . 1987PNAS...84.2238S . free .
• Kiyohara H, Menjo M . Ribonuclease and ribonuclease inhibitor in the human pancreas . Gastroenterol. Jpn. . 18 . 5 . 468–73 . 1984 . 6653993 . 10.1007/BF02776587. 10963236 .
• Nadano D, Yasuda T, Takeshita H, etal . Purification and characterization of human brain ribonuclease inhibitor . Arch. Biochem. Biophys. . 312 . 2 . 421–8 . 1994 . 8037455 . 10.1006/abbi.1994.1328 .
• Kobe B, Deisenhofer J . Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats . Nature . 366 . 6457 . 751–6 . 1994 . 8264799 . 10.1038/366751a0 . 34579479 .
• Papageorgiou AC, Shapiro R, Acharya KR . Molecular recognition of human angiogenin by placental ribonuclease inhibitor--an X-ray crystallographic study at 2.0 A resolution . EMBO J. . 16 . 17 . 5162–77 . 1997 . 9311977 . 10.1093/emboj/16.17.5162 . 1170149 .
• Gaur D, Swaminathan S, Batra JK . Interaction of human pancreatic ribonuclease with human ribonuclease inhibitor. Generation of inhibitor-resistant cytotoxic variants . J. Biol. Chem. . 276 . 27 . 24978–84 . 2001 . 11342552 . 10.1074/jbc.M102440200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Fu P, Chen J, Tian Y, etal . Anti-tumor effect of hematopoietic cells carrying the gene of ribonuclease inhibitor . Cancer Gene Ther. . 12 . 3 . 268–75 . 2005 . 15592448 . 10.1038/sj.cgt.7700742 . free .
• Iyer S, Holloway DE, Kumar K, etal . Molecular recognition of human eosinophil-derived neurotoxin (RNase 2) by placental ribonuclease inhibitor . J. Mol. Biol. . 347 . 3 . 637–55 . 2005 . 15755456 . 10.1016/j.jmb.2005.01.035 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Johnson RJ, McCoy JG, Bingman CA, etal . Inhibition of Human Pancreatic Ribonuclease by the Human Ribonuclease Inhibitor Protein . J. Mol. Biol. . 368 . 2 . 434–49 . 2007 . 17350650 . 10.1016/j.jmb.2007.02.005 . 1993901 .

Notes and References

1. Web site: Entrez Gene: RNH1 ribonuclease/angiogenin inhibitor 1.