RNGTT explained

mRNA-capping enzyme is a protein that in humans is encoded by the RNGTT gene.^{[1] [2] [3]}

Further reading

• Yue Z . Mammalian capping enzyme complements mutant Saccharomyces cerevisiae lacking mRNA guanylyltransferase and selectively binds the elongating form of RNA polymerase II . Proc. Natl. Acad. Sci. U.S.A. . 94 . 24 . 12898–903 . 1998 . 9371772 . 10.1073/pnas.94.24.12898 . 24235 . Maldonado E . Pillutla R . Cho . H . Reinberg . D . Shatkin . AJ . free .
• Tsukamoto T . Cloning and characterization of two human cDNAs encoding the mRNA capping enzyme . Biochem. Biophys. Res. Commun. . 243 . 1 . 101–8 . 1998 . 9473487 . 10.1006/bbrc.1997.8038 . Shibagaki Y . Murakoshi T . Suzuki . Masako . Nakamura . Akiko . Gotoh . Hideo . Mizumoto . Kiyohisa .
• Pillutla RC, Yue Z, Maldonado E, Shatkin AJ . Recombinant human mRNA cap methyltransferase binds capping enzyme/RNA polymerase IIo complexes . J. Biol. Chem. . 273 . 34 . 21443–6 . 1998 . 9705270 . 10.1074/jbc.273.34.21443 . free.
• Wen Y, Shatkin AJ . Transcription elongation factor hSPT5 stimulates mRNA capping . Genes Dev. . 13 . 14 . 1774–9 . 1999 . 10421630 . 10.1101/gad.13.14.1774 . 316881 .
• Chiu YL . HIV-1 Tat protein interacts with mammalian capping enzyme and stimulates capping of TAR RNA . J. Biol. Chem. . 276 . 16 . 12959–66 . 2001 . 11278368 . 10.1074/jbc.M007901200 . Coronel E . Ho CK . Shuman . S . Rana . TM . free .
• Chiu YL . Tat stimulates cotranscriptional capping of HIV mRNA . Mol. Cell . 10 . 3 . 585–97 . 2002 . 12408826 . 10.1016/S1097-2765(02)00630-5 . Ho CK . Saha N . Schwer . Beate . Shuman . Stewart . Rana . Tariq M . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Zhou M . The Tat/TAR-dependent phosphorylation of RNA polymerase II C-terminal domain stimulates cotranscriptional capping of HIV-1 mRNA . Proc. Natl. Acad. Sci. U.S.A. . 100 . 22 . 12666–71 . 2004 . 14569024 . 10.1073/pnas.1835726100 . 240675 . Deng L . Kashanchi F . Brady . JN . Shatkin . AJ . Kumar . A . free .
• Suzuki Y . Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions . Genome Res. . 14 . 9 . 1711–8 . 2004 . 15342556 . 10.1101/gr.2435604 . 515316 . Yamashita R . Shirota M . Sakakibara . Y . Chiba . J . Mizushima-Sugano . J . Nakai . K . Sugano . S .
• Olsen JV . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . Blagoev B . Gnad F . Macek . Boris . Kumar . Chanchal . Mortensen . Peter . Mann . Matthias . 7827573 . free.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human mRNA-capping enzyme (RNGTT)

Notes and References

1. Pillutla RC, Shimamoto A, Furuichi Y, Shatkin AJ . Human mRNA capping enzyme (RNGTT) and cap methyltransferase (RNMT) map to 6q16 and 18p11.22-p11.23, respectively . Genomics . 54 . 2 . 351–3 . Jan 1999 . 9828141 . 10.1006/geno.1998.5604 .
2. Yamada-Okabe T, Doi R, Shimmi O, Arisawa M, Yamada-Okabe H . Isolation and characterization of a human cDNA for mRNA 5'-capping enzyme . Nucleic Acids Res . 26 . 7 . 1700–6 . May 1998 . 9512541 . 147440 . 10.1093/nar/26.7.1700 .
3. Web site: Entrez Gene: RNGTT RNA guanylyltransferase and 5'-phosphatase.