RNF5 explained

E3 ubiquitin-protein ligase RNF5 is an enzyme that in humans is encoded by the RNF5 gene.^{[1] [2]}

Function

The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions.

Further reading

• Kendall E, Sargent CA, Campbell RD . Human major histocompatibility complex contains a new cluster of genes between the HLA-D and complement C4 loci . Nucleic Acids Research . 18 . 24 . 7251–7 . December 1990 . 2259622 . 332860 . 10.1093/nar/18.24.7251 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Research . 6 . 9 . 791–806 . September 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
• Barritt DS, Pearn MT, Zisch AH, Lee SS, Javier RT, Pasquale EB, Stallcup WB . The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2 . Journal of Cellular Biochemistry . 79 . 2 . 213–24 . August 2000 . 10967549 . 3501957 . 10.1002/1097-4644(20001101)79:2<213::AID-JCB50>3.0.CO;2-G .
• Matsuda N, Suzuki T, Tanaka K, Nakano A . Rma1, a novel type of RING finger protein conserved from Arabidopsis to human, is a membrane-bound ubiquitin ligase . Journal of Cell Science . 114 . Pt 10 . 1949–57 . May 2001 . 10.1242/jcs.114.10.1949 . 11329381 .
• Pouly S, Prat A, Blain M, Olivier A, Antel J . NG2 immunoreactivity on human brain endothelial cells . Acta Neuropathologica . 102 . 4 . 313–20 . October 2001 . 11603805 . 10.1007/s004010000350 . 1353236 .
• Didier C, Broday L, Bhoumik A, Israeli S, Takahashi S, Nakayama K, Thomas SM, Turner CE, Henderson S, Sabe H, Ronai Z . RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization . Molecular and Cellular Biology . 23 . 15 . 5331–45 . August 2003 . 12861019 . 165736 . 10.1128/MCB.23.15.5331-5345.2003 .
• Xie T, Rowen L, Aguado B, Ahearn ME, Madan A, Qin S, Campbell RD, Hood L . Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse . Genome Research . 13 . 12 . 2621–36 . December 2003 . 14656967 . 403804 . 10.1101/gr.1736803 .
• Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM . Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region . Genomics . 83 . 1 . 153–67 . January 2004 . 14667819 . 10.1016/S0888-7543(03)00235-0 .
• Liu AM, Wong YH . G16-mediated activation of nuclear factor kappaB by the adenosine A1 receptor involves c-Src, protein kinase C, and ERK signaling . The Journal of Biological Chemistry . 279 . 51 . 53196–204 . December 2004 . 15485865 . 10.1074/jbc.M410196200 . free .
• Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL . High-throughput mapping of a dynamic signaling network in mammalian cells . Science . 307 . 5715 . 1621–5 . March 2005 . 15761153 . 10.1126/science.1105776 . 2005Sci...307.1621B . 39457788 .
• Zhang Y, Higashide W, Dai S, Sherman DM, Zhou D . Recognition and ubiquitination of Salmonella type III effector SopA by a ubiquitin E3 ligase, HsRMA1 . The Journal of Biological Chemistry . 280 . 46 . 38682–8 . November 2005 . 16176924 . 10.1074/jbc.M506309200 . free .
• Younger JM, Chen L, Ren HY, Rosser MF, Turnbull EL, Fan CY, Patterson C, Cyr DM . Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator . Cell . 126 . 3 . 571–82 . August 2006 . 16901789 . 10.1016/j.cell.2006.06.041 . 51698 . free .
• Bromberg KD, Kluger HM, Delaunay A, Abbas S, DiVito KA, Krajewski S, Ronai Z . Increased expression of the E3 ubiquitin ligase RNF5 is associated with decreased survival in breast cancer . Cancer Research . 67 . 17 . 8172–9 . September 2007 . 17804730 . 2962863 . 10.1158/0008-5472.CAN-07-0045 .
• Fujita Y, Khateb A, Li Y, Tinoco R, Zhang T, Bar-Yoseph H, Tam MA, Chowers Y, Sabo E, Gerassy-Vainberg S, Starosvetsky E, James B, Brown K, Shen-Orr SS, Bradley LM, Tessier PA, Ronai ZA . Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis . Cell Reports . 24 . 12 . 3296–3311.e6 . September 2018 . 30232010 . 6185744 . 10.1016/j.celrep.2018.08.057 .

Notes and References

1. Kyushiki H, Kuga Y, Suzuki M, Takahashi E, Horie M . Cloning, expression and mapping of a novel RING-finger gene (RNF5), a human homologue of a putative zinc-finger gene from Caenorhabditis elegans . Cytogenetics and Cell Genetics . 79 . 1–2 . 114–7 . Apr 1998 . 9533025 . 10.1159/000134695 .
2. Web site: Entrez Gene: RNF5 ring finger protein 5.