RNF41 explained

E3 ubiquitin-protein ligase NRDP1 is an enzyme that in humans is encoded by the RNF41 gene.^[1]

Function

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The specific function of this protein has not yet been determined. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.

Interactions

RNF41 has been shown to interact with USP8.^[2]

See also

• RING finger domain

Further reading

• Cao Z, Wu X, Yen L, Sweeney C, Carraway KL . Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1 . Mol. Cell. Biol. . 27 . 6 . 2180–8 . 2007 . 17210635 . 1820496 . 10.1128/MCB.01245-06 .
• Avvakumov GV, Walker JR, Xue S, Finerty PJ, Mackenzie F, Newman EM, Dhe-Paganon S . Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8) . J. Biol. Chem. . 281 . 49 . 38061–70 . 2006 . 17035239 . 10.1074/jbc.M606704200 . free .
• Wu X, Yen L, Irwin L, Sweeney C, Carraway KL . Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8 . Mol. Cell. Biol. . 24 . 17 . 7748–57 . 2004 . 15314180 . 506982 . 10.1128/MCB.24.17.7748-7757.2004 .
• Qiu XB, Markant SL, Yuan J, Goldberg AL . Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis . EMBO J. . 23 . 4 . 800–10 . 2004 . 14765125 . 380992 . 10.1038/sj.emboj.7600075 .
• Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G . Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network . J. Biol. Chem. . 279 . 13 . 12804–11 . 2004 . 14676191 . 10.1074/jbc.M312171200 . free .
• Qiu XB, Goldberg AL . Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3 . Proc. Natl. Acad. Sci. U.S.A. . 99 . 23 . 14843–8 . 2002 . 12411582 . 137506 . 10.1073/pnas.232580999 . 2002PNAS...9914843Q . free .
• Diamonti AJ, Guy PM, Ivanof C, Wong K, Sweeney C, Carraway KL . An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels . Proc. Natl. Acad. Sci. U.S.A. . 99 . 5 . 2866–71 . 2002 . 11867753 . 122439 . 10.1073/pnas.052709799 . 2002PNAS...99.2866D . free .
• Abdullah JM, Li X, Nachtman RG, Jurecic R . FLRF, a novel evolutionarily conserved RING finger gene, is differentially expressed in mouse fetal and adult hematopoietic stem cells and progenitors . Blood Cells Mol. Dis. . 27 . 1 . 320–33 . 2001 . 11358394 . 10.1006/bcmd.2001.0390 .
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA . Large-scale concatenation cDNA sequencing . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 139146 . 10.1101/gr.7.4.353 .
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA . A "double adaptor" method for improved shotgun library construction . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 .

Notes and References

1. Web site: Entrez Gene: RNF41 ring finger protein 41.
2. Wu X, Yen L, Irwin L, Sweeney C, Carraway KL . Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8 . Mol. Cell. Biol. . 24 . 17 . 7748–57 . September 2004 . 15314180 . 506982 . 10.1128/MCB.24.17.7748-7757.2004 .