RNF20 explained

E3 ubiquitin-protein ligase BRE1A is an enzyme that in humans is encoded by the RNF20 gene.^{[1] [2] [3] [4] [5]}

The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. Yeast BRE1 is a ubiquitin ligase required for the ubiquitination of histone H2B and the methylation of histone H3.^[6]

See also

• RING finger domain

Further reading

• Lossos IS, Alizadeh AA, Eisen MB, etal . Ongoing immunoglobulin somatic mutation in germinal center B cell-like but not in activated B cell-like diffuse large cell lymphomas. . Proc. Natl. Acad. Sci. U.S.A. . 97 . 18 . 10209–13 . 2000 . 10954754 . 10.1073/pnas.180316097 . 27813 . 2000PNAS...9710209L . free .
• Slachta CA, Jeevanandam V, Goldman B, etal . Coronary arteries from human cardiac allografts with chronic rejection contain oligoclonal T cells: persistence of identical clonally expanded TCR transcripts from the early post-transplantation period (endomyocardial biopsies) to chronic rejection (coronary arteries). . J. Immunol. . 165 . 6 . 3469–83 . 2000 . 10975868 . 10.4049/jimmunol.165.6.3469. free .
• Lee J, Monson NL, Lipsky PE . The V lambda J lambda repertoire in human fetal spleen: evidence for positive selection and extensive receptor editing. . J. Immunol. . 165 . 11 . 6322–33 . 2001 . 11086069 . 10.4049/jimmunol.165.11.6322. free .
• Rowley AH, Shulman ST, Spike BT, etal . Oligoclonal IgA response in the vascular wall in acute Kawasaki disease. . J. Immunol. . 166 . 2 . 1334–43 . 2001 . 11145718 . 10.4049/jimmunol.166.2.1334. free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Hwang WW, Venkatasubrahmanyam S, Ianculescu AG, etal . A conserved RING finger protein required for histone H2B monoubiquitination and cell size control. . Mol. Cell . 11 . 1 . 261–6 . 2003 . 12535538 . 10.1016/S1097-2765(02)00826-2 . free .
• Wood A, Krogan NJ, Dover J, etal . Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter. . Mol. Cell . 11 . 1 . 267–74 . 2003 . 12535539 . 10.1016/S1097-2765(02)00802-X . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Humphray SJ, Oliver K, Hunt AR, etal . DNA sequence and analysis of human chromosome 9. . Nature . 429 . 6990 . 369–74 . 2004 . 15164053 . 10.1038/nature02465 . 2734081 . 2004Natur.429..369H .
• Beausoleil SA, Jedrychowski M, Schwartz D, etal . Large-scale characterization of HeLa cell nuclear phosphoproteins. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . 2004PNAS..10112130B . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Andersen JS, Lam YW, Leung AK, etal . Nucleolar proteome dynamics. . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 .
• Zhu B, Zheng Y, Pham AD, etal . Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. . Mol. Cell . 20 . 4 . 601–11 . 2006 . 16307923 . 10.1016/j.molcel.2005.09.025 . free .

Notes and References

1. Kim J, Hake SB, Roeder RG . The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions . Mol Cell . 20 . 5 . 759–70 . Dec 2005 . 16337599 . 10.1016/j.molcel.2005.11.012 . free .
2. Wood A, Schneider J, Dover J, Johnston M, Shilatifard A . The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p . J Biol Chem . 278 . 37 . 34739–42 . Sep 2003 . 12876294 . 10.1074/jbc.C300269200 . free .
3. Shema E, Tirosh I, Aylon Y, Huang J, Ye C, Moskovits N, Raver-Shapira N, Minsky N, Pirngruber J, Tarcic G, Hublarova P, Moyal L, Gana-Weisz M, Shiloh Y, Yarden Y, Johnsen SA, Vojtesek B, Berger SL, Oren M . The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression . Genes Dev . 22 . 19 . 2664–76 . Oct 2008 . 18832071 . 2559905 . 10.1101/gad.1703008 .
4. Liu Z, Oh SM, Okada M, Liu X, Cheng D, Peng J, Brat DJ, Sun SY, Zhou W, Gu W, Ye K . Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor . Mol Biol Cell . 20 . 3 . 757–68 . Feb 2009 . 19037095 . 2633391 . 10.1091/mbc.E08-09-0983 .
5. Web site: Entrez Gene: RNF20 ring finger protein 20.
6. Web site: Entrez Gene: RNF20 ring finger protein 20.