RNF139 explained

RING finger protein 139, also known as TRC8, is a protein that in humans is encoded by the RNF139 gene.^{[1] [2]}

The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medullary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP].^[3]

Further reading

• Poland KS, Azim M, Folsom M, etal . A constitutional balanced t(3;8)(p14;q24.1) translocation results in disruption of the TRC8 gene and predisposition to clear cell renal cell carcinoma. . Genes Chromosomes Cancer . 46 . 9 . 805–12 . 2007 . 17539022 . 10.1002/gcc.20466 . 44344160 . free .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Brauweiler A, Lorick KL, Lee JP, etal . RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene. . Oncogene . 26 . 16 . 2263–71 . 2007 . 17016439 . 10.1038/sj.onc.1210017 . 12979173 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gemmill RM, Bemis LT, Lee JP, etal . The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway. . Oncogene . 21 . 22 . 3507–16 . 2002 . 12032852 . 10.1038/sj.onc.1205437 . 9964634 .
• Lorick KL, Jensen JP, Fang S, etal . RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. . Proc. Natl. Acad. Sci. U.S.A. . 96 . 20 . 11364–9 . 1999 . 10500182 . 10.1073/pnas.96.20.11364 . 18039 . 1999PNAS...9611364L . free .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .

Notes and References

1. Gemmill RM, West JD, Boldog F, Tanaka N, Robinson LJ, Smith DI, Li F, Drabkin HA . The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8 . Proc Natl Acad Sci U S A . 95 . 16 . 9572–7 . Sep 1998 . 9689122 . 21380 . 10.1073/pnas.95.16.9572 . 1998PNAS...95.9572G . free .
2. Web site: Entrez Gene: RNF139 ring finger protein 139.
3. Web site: Entrez Gene: RNF139 ring finger protein 139.