RNF135 explained

RING finger protein 135 is a protein that in humans is encoded by the RNF135 gene.^{[1] [2] [3]}

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Interactions

RNF135 has been shown to interact with RARRES3.

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Jenne DE, Tinschert S, Dorschner MO, etal . Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse. . Genes Chromosomes Cancer . 37 . 2 . 111–20 . 2003 . 12696059 . 10.1002/gcc.10206 . 37232718 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Petroziello J, Yamane A, Westendorf L, etal . Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. . Oncogene . 23 . 46 . 7734–45 . 2004 . 15334068 . 10.1038/sj.onc.1207921 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Douglas J, Cilliers D, Coleman K, etal . Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth. . Nat. Genet. . 39 . 8 . 963–5 . 2007 . 17632510 . 10.1038/ng2083 . 35797973 .

Notes and References

1. Jenne DE, Tinschert S, Reimann H, Lasinger W, Thiel G, Hameister H, Kehrer-Sawatzki H . Molecular characterization and gene content of breakpoint boundaries in patients with neurofibromatosis type 1 with 17q11.2 microdeletions . Am J Hum Genet . 69 . 3 . 516–27 . Aug 2001 . 11468690 . 1235482 . 10.1086/323043 .
2. Oshiumi H, Matsumoto M, Hatakeyama S, Seya T . Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection . J Biol Chem . 284 . 2 . 807–17 . Jan 2009 . 19017631 . 10.1074/jbc.M804259200 . free .
3. Web site: Entrez Gene: RNF135 ring finger protein 135.