RNF11 explained

RING finger protein 11 is a protein that in humans is encoded by the RNF11 gene.^{[1] [2] [3]}

Function

The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN).

See also

• RING finger domain

Interactions

RNF11 has been shown to interact with RIPK1^[4] and STAMBP.^[5]

Further reading

• Burger A, Amemiya Y, Kitching R, Seth AK . Novel RING E3 ubiquitin ligases in breast cancer . Neoplasia . 8 . 8 . 689–95 . 2006 . 16925951 . 1601945 . 10.1593/neo.06469 .
• Jolliffe CN, Harvey KF, Haines BP, Parasivam G, Kumar S . Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4 . Biochem. J. . 351 Pt 3 . 3. 557–65 . 2000 . 11042109 . 1221394 . 10.1042/0264-6021:3510557 .
• Watanabe T, Ichihara M, Hashimoto M, Shimono K, Shimoyama Y, Nagasaka T, Murakumo Y, Murakami H, Sugiura H, Iwata H, Ishiguro N, Takahashi M . Characterization of gene expression induced by RET with MEN2A or MEN2B mutation . Am. J. Pathol. . 161 . 1 . 249–56 . 2002 . 12107109 . 1850689 . 10.1016/S0002-9440(10)64176-4 .
• Kitching R, Wong MJ, Koehler D, Burger AM, Landberg G, Gish G, Seth A . The RING-H2 protein RNF11 is differentially expressed in breast tumours and interacts with HECT-type E3 ligases . Biochim. Biophys. Acta . 1639 . 2 . 104–12 . 2003 . 14559117 . 10.1016/j.bbadis.2003.07.001 .
• Subramaniam V, Li H, Wong M, Kitching R, Attisano L, Wrana J, Zubovits J, Burger AM, Seth A . The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase . Br. J. Cancer . 89 . 8 . 1538–44 . 2003 . 14562029 . 2394340 . 10.1038/sj.bjc.6601301 .
• Li H, Seth A . An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein . Oncogene . 23 . 10 . 1801–8 . 2004 . 14755250 . 10.1038/sj.onc.1207319 . 37253372 .
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM . Functional proteomics mapping of a human signaling pathway . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 442148 . 10.1101/gr.2334104 .
• Connor MK, Azmi PB, Subramaniam V, Li H, Seth A . Molecular characterization of ring finger protein 11 . Mol. Cancer Res. . 3 . 8 . 453–61 . 2005 . 16123141 . 10.1158/1541-7786.MCR-04-0166 . 24739627 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
• Anderson LR, Betarbet R, Gearing M, Gulcher J, Hicks AA, Stefánsson K, Lah JJ, Levey AI . PARK10 candidate RNF11 is expressed by vulnerable neurons and localizes to Lewy bodies in Parkinson disease brain . J. Neuropathol. Exp. Neurol. . 66 . 10 . 955–64 . 2007 . 17917589 . 10.1097/nen.0b013e3181567f17 . free .

Notes and References

1. Seki N, Hattori A, Hayashi A, Kozuma S, Sasaki M, Suzuki Y, Sugano S, Muramatsu MA, Saito T . Cloning and expression profile of mouse and human genes, Rnf11/RNF11, encoding a novel RING-H2 finger protein . Biochim. Biophys. Acta . 1489 . 2–3 . 421–7 . December 1999 . 10673045 . 10.1016/s0167-4781(99)00190-6 .
2. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W . Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics . Genome Res. . 10 . 5 . 703–13 . August 2000 . 10810093 . 310876 . 10.1101/gr.10.5.703 .
3. Web site: Entrez Gene: RNF11 ring finger protein 11.
4. Shembade N, Parvatiyar K, Harhaj NS, Harhaj EW . The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling . EMBO J. . 28 . 5 . 513–22 . March 2009 . 19131965 . 2657574 . 10.1038/emboj.2008.285 .
5. Li H, Seth A . An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein . Oncogene . 23 . 10 . 1801–8 . March 2004 . 14755250 . 10.1038/sj.onc.1207319 . 37253372 .