RNA uridylyltransferase explained

RNA uridylyltransferase
Ec Number:	2.7.7.52
Cas Number:	78519-53-6
Go Code:	0050265

In enzymology, a RNA uridylyltransferase is an enzyme that catalyzes the chemical reaction

UTP + RNA_n

\rightleftharpoons diphosphate + RNA_n+1

Thus, the two substrates of this enzyme are UTP and RNA_n, whereas its two products are diphosphate and RNA_n+1.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is UTP:RNA uridylyltransferase. Other names in common use include terminal uridylyltransferase, and TUT.

Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes,,,,,,, and .

References

• Zabel P, Dorssers L, Wernars K, Van Kammen A . Terminal uridylyl transferase of Vigna unguiculata: purification and characterization of an enzyme catalyzing the addition of a single UMP residue to the 3'-end of an RNA primer . Nucleic Acids Research . 9 . 11 . 2433–53 . June 1981 . 6269049 . 326863 . 10.1093/nar/9.11.2433 . Ab van Kammen .