RNA binding motif protein, Y-linked, family 1, member A1 explained

RNA-binding motif protein, Y chromosome, family 1 member A1/C is a protein that in humans is encoded by the RBMY1A1 gene.^{[1] [2] [3]}

This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region of chromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus are pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked. Alternative splicing of transcripts results in two transcript variants that encode different proteins.^[3]

Further reading

• Lavery R, Glennon M, Houghton J, etal . Investigation of DAZ and RBMY1 gene expression in human testis by quantitative real-time PCR. . Arch. Androl. . 53 . 2 . 71–3 . 2007 . 17453684 . 10.1080/01485010600915228 . 22899385 .
• Skrisovska L, Bourgeois CF, Stefl R, etal . The testis-specific human protein RBMY recognizes RNA through a novel mode of interaction. . EMBO Rep. . 8 . 4 . 372–9 . 2007 . 17318228 . 10.1038/sj.embor.7400910 . 1852761.
• Lindtner S, Zolotukhin AS, Uranishi H, etal . RNA-binding motif protein 15 binds to the RNA transport element RTÉ and provides a direct link to the NXF1 export pathway. . J. Biol. Chem. . 281 . 48 . 36915–28 . 2007 . 17001072 . 10.1074/jbc.M608745200 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 528928 . 10.1101/gr.2596504 .
• Tsuei DJ, Hsu HC, Lee PH, etal . RBMY, a male germ cell-specific RNA-binding protein, activated in human liver cancers and transforms rodent fibroblasts. . Oncogene . 23 . 34 . 5815–22 . 2004 . 15184870 . 10.1038/sj.onc.1207773 . 20055243 .
• Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, etal . The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. . Nature . 423 . 6942 . 825–37 . 2003 . 12815422 . 10.1038/nature01722 . 2003Natur.423..825S . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 139241 . 10.1073/pnas.242603899 . free . 2002PNAS...9916899M .
• Chang Mei-hwei . Chen Pei-jer . Tsuei DJ, Chang MH, Chen PJ, etal . Characterization of integration patterns and flanking cellular sequences of hepatitis B virus in childhood hepatocellular carcinomas. . J. Med. Virol. . 68 . 4 . 513–21 . 2003 . 12376959 . 10.1002/jmv.10240 . 26869562 .
• Friel A, Houghton JA, Glennon M, etal . A preliminary report on the implication of RT-PCR detection of DAZ, RBMY1, USP9Y and Protamine-2 mRNA in testicular biopsy samples from azoospermic men. . Int. J. Androl. . 25 . 1 . 59–64 . 2002 . 11869379 . 10.1046/j.1365-2605.2002.00326.x . free .
• Pellizzoni L, Charroux B, Rappsilber J, etal . A functional interaction between the survival motor neuron complex and RNA polymerase II. . J. Cell Biol. . 152 . 1 . 75–85 . 2001 . 11149922 . 2193649 . 10.1083/jcb.152.1.75 .
• Elliott DJ, Bourgeois CF, Klink A, etal . A mammalian germ cell-specific RNA-binding protein interacts with ubiquitously expressed proteins involved in splice site selection. . Proc. Natl. Acad. Sci. U.S.A. . 97 . 11 . 5717–22 . 2000 . 10823932 . 18499 . 10.1073/pnas.97.11.5717 . 2000PNAS...97.5717E . free .
• Venables JP, Elliott DJ, Makarova OV, etal . RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing. . Hum. Mol. Genet. . 9 . 5 . 685–94 . 2000 . 10749975 . 10.1093/hmg/9.5.685. free .
• Elliott DJ, Oghene K, Makarov G, etal . Dynamic changes in the subnuclear organisation of pre-mRNA splicing proteins and RBM during human germ cell development. . J. Cell Sci. . 111 . 9. 1255–65 . 1998 . 10.1242/jcs.111.9.1255 . 9547301 .
• Prosser J, Inglis JD, Condie A, etal . Degeneracy in human multicopy RBM (YRRM), a candidate spermatogenesis gene. . Mamm. Genome . 7 . 11 . 835–42 . 1997 . 8875892 . 10.1007/s003359900246 . 23907707 .

Notes and References

1. Ma K, Inglis JD, Sharkey A, Bickmore WA, Hill RE, Prosser EJ, Speed RM, Thomson EJ, Jobling M, Taylor K, etal . A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis . Cell . 75 . 7 . 1287–95 . Jan 1994 . 8269511 . 10.1016/0092-8674(93)90616-X . 24678568 .
2. Chai NN, Zhou H, Hernandez J, Najmabadi H, Bhasin S, Yen PH . Structure and organization of the RBMY genes on the human Y chromosome: transposition and amplification of an ancestral autosomal hnRNPG gene . Genomics . 49 . 2 . 283–9 . Aug 1998 . 9598316 . 10.1006/geno.1998.5255 .
3. Web site: Entrez Gene: RBMY1A1 RNA binding motif protein, Y-linked, family 1, member A1.