RnaG explained

RnaG sRNA
Rfam:	RF02550
Tax Domain:	Bacteria
So:	,

RnaG is a small regulatory non-coding RNA encoded by the virulence plasmid of Shigella flexneri, a Gram-negative pathogenic bacterium that causes human bacillary dysentery. It is a first regulatory RNA characterised in S. flexneri. The RNA is 450 nucleotides long (which makes it one of the largest regulatory sRNAs) and it contains a region with specific secondary structure that interacts with icsA (virG) mRNA and forms a transcription terminator. Acting as antisense, RnaG is transcribed from the complementary strand of its target, icsA mRNA.^[1] The activity of the incA protein is crucial for spreading of the bacterial pathogen in the host cells.^[2]

Notes and References

1. Giangrossi M, Prosseda G, Tran CN, Brandi A, Colonna B, Falconi M . A novel antisense RNA regulates at transcriptional level the virulence gene icsA of Shigella flexneri . Nucleic Acids Research . 38 . 10 . 3362–3375 . June 2010 . 20129941 . 2879508 . 10.1093/nar/gkq025 .
2. Bernardini ML, Mounier J, d'Hauteville H, Coquis-Rondon M, Sansonetti PJ . Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actin . Proceedings of the National Academy of Sciences of the United States of America . 86 . 10 . 3867–3871 . May 1989 . 2542950 . 287242 . 10.1073/pnas.86.10.3867 . free .