RJR-2429 explained
RJR-2429 is a drug that acts as an agonist at neural nicotinic acetylcholine receptors, binding to both the α3β4 and the α4β2 subtypes. RJR-2429 is stronger than nicotine but weaker than epibatidine in most assays, and with high affinity for both α3β4 and α4β2 subtypes, as well as the less studied α1βγδ subtype.[1] [2] [3]
Notes and References
- Bencherif M, Schmitt JD, Bhatti BS, Crooks P, Caldwell WS, Lovette ME, Fowler K, Reeves L, Lippiello PM . 6 . The heterocyclic substituted pyridine derivative (+/-)-2-(-3-pyridinyl)-1-azabicyclo[2.2.2]octane (RJR-2429): a selective ligand at nicotinic acetylcholine receptors . The Journal of Pharmacology and Experimental Therapeutics . 284 . 3 . 886–94 . March 1998 . 9495846 .
- Yokotani K, Okada S, Nakamura K . Characterization of functional nicotinic acetylcholine receptors involved in catecholamine release from the isolated rat adrenal gland . European Journal of Pharmacology . 446 . 1–3 . 83–7 . June 2002 . 12098588 . 10.1016/s0014-2999(02)01819-8 .
- Bhatti BS, Strachan JP, Breining SR, Miller CH, Tahiri P, Crooks PA, Deo N, Day CS, Caldwell WS . 6 . Synthesis of 2-(pyridin-3-yl)-1-azabicyclo[3.2.2]nonane, 2-(pyridin-3-yl)-1-azabicyclo[2.2.2]octane, and 2-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, a class of potent nicotinic acetylcholine receptor-ligands . The Journal of Organic Chemistry . 73 . 9 . 3497–507 . May 2008 . 18363376 . 10.1021/jo800028q .
