RIPK4 explained

Receptor-interacting serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the RIPK4 gene.^{[1] [2]}

The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation.

Interactions

RIPK4 has been shown to interact with PRKCB1.^[3]

Further reading

• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Bhr C, Rohwer A, Stempka L, etal . DIK, a novel protein kinase that interacts with protein kinase Cdelta. Cloning, characterization, and gene analysis . J. Biol. Chem. . 275 . 46 . 36350–7 . 2000 . 10948194 . 10.1074/jbc.M004771200 . free .
• Chen L, Haider K, Ponda M, etal . Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase . J. Biol. Chem. . 276 . 24 . 21737–44 . 2001 . 11278382 . 10.1074/jbc.M008069200 . free .
• Meylan E, Martinon F, Thome M, etal . RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-κB and is processed during apoptosis . EMBO Rep. . 3 . 12 . 1201–8 . 2003 . 12446564 . 10.1093/embo-reports/kvf236 . 1308326 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Moran ST, Haider K, Ow Y, etal . Protein kinase C-associated kinase can activate NFkappaB in both a kinase-dependent and a kinase-independent manner . J. Biol. Chem. . 278 . 24 . 21526–33 . 2003 . 12676934 . 10.1074/jbc.M301575200 . free .
• Scanlan MJ, Gout I, Gordon CM, etal . Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression . Cancer Immun. . 1 . 4 . 2003 . 12747765 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Adams S, Pankow S, Werner S, Munz B . Regulation of NF-kappaB activity and keratinocyte differentiation by the RIP4 protein: implications for cutaneous wound repair . J. Invest. Dermatol. . 127 . 3 . 538–44 . 2007 . 17039240 . 10.1038/sj.jid.5700588 . free .

Notes and References

1. Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML . The DNA sequence of human chromosome 21 . Nature . 405 . 6784 . 311–9 . June 2000 . 10830953 . 10.1038/35012518 . free . 2000Natur.405..311H .
2. Web site: Entrez Gene: RIPK4 receptor-interacting serine-threonine kinase 4.
3. Chen . L . Haider K . Ponda M . Cariappa A . Rowitch D . Pillai S . June 2001 . Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase . J. Biol. Chem. . 276 . 24 . 21737–44 . 0021-9258. 11278382 . 10.1074/jbc.M008069200 . free .