RIN1 explained

Ras and Rab interactor 1 is a protein that in humans is encoded by the RIN1 gene.^{[1] [2] [3]}

Interactions

RIN1 has been shown to interact with HRAS.^{[4] [5]}

Additionally, RIN1 binds and activates ABL family tyrosine kinases.

Further reading

• Dkaha A, Costa RM, Hu H, Irvin DK, Patel A, Kornblum HI, Silva AJ, O'Dell TJ, Colicelli J . The RAS effector RIN1 modulates the formation of aversive memories . J. Neurosci. . 23 . 3 . 748–757 . 2003 . 12574403. 10.1523/JNEUROSCI.23-03-00748.2003. 6741936 .
• Trowbridge IS, Lesley J, Trotter J, Hyman R . Thymocyte subpopulation enriched for progenitors with an unrearranged T-cell receptor beta-chain gene . Nature . 315 . 6021 . 666–9 . 1985 . 3874369 . 10.1038/315666a0 . 1985Natur.315..666T . 20469621 .
• Han L, Colicelli J . A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1 . Mol. Cell. Biol. . 15 . 3 . 1318–23 . 1995 . 7862125 . 10.1128/mcb.15.3.1318. 230355 .
• Afar DE . Regulation of the oncogenic activity of BCR-ABL by a tightly bound substrate protein RIN1 . Immunity . 6 . 6 . 773–82 . 1997 . 9208849 . 10.1016/S1074-7613(00)80452-5 . Han L . McLaughlin J . Wong . Stephane . Dhaka . Ajay . Parmar . Kalindi . Rosenberg . Naomi . Witte . Owen N . Colicelli . John . free .
• Tall GG, Barbieri MA, Stahl PD, Horazdovsky BF . Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1 . Dev. Cell . 1 . 1 . 73–82 . 2001 . 11703925 . 10.1016/S1534-5807(01)00008-9 . free .
• Wang Y . The RAS Effector RIN1 Directly Competes with RAF and Is Regulated by 14-3-3 Proteins . Mol. Cell. Biol. . 22 . 3 . 916–26 . 2002 . 11784866 . 10.1128/MCB.22.3.916-926.2001 . 133556 . Waldron RT . Dhaka A . Patel . A. . Riley . M. M. . Rozengurt . E. . Colicelli . J. .
• Murphy GA . Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation . J. Biol. Chem. . 277 . 12 . 9966–75 . 2002 . 11788587 . 10.1074/jbc.M109059200 . Graham SM . Morita S . Reks . SE . Rogers-Graham . K . Vojtek . A . Kelley . GG . Der . CJ . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M. free .
• Mitin NY . Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization . J. Biol. Chem. . 279 . 21 . 22353–61 . 2004 . 15031288 . 10.1074/jbc.M312867200 . Ramocki MB . Zullo AJ . Der . CJ . Konieczny . SF . Taparowsky . EJ . free.
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Hu H, Bliss JM, Wang Y, Colicelli J . RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration . Curr. Biol. . 15 . 9 . 815–23 . 2005 . 15886098 . 10.1016/j.cub.2005.03.049 . 6736561 . free . 2005CBio...15..815H .
• Zhang Y . Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules . Mol. Cell. Proteomics . 4 . 9 . 1240–50 . 2005 . 15951569 . 10.1074/mcp.M500089-MCP200 . Wolf-Yadlin A . Ross PL . Pappin . DJ . Rush . J . Lauffenburger . DA . White . FM . free .
• Rual JF . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . Venkatesan K . Hao T . Hirozane-Kishikawa . Tomoko . Dricot . Amélie . Li . Ning . Berriz . Gabriel F. . Gibbons . Francis D. . Dreze . Matija . 2005Natur.437.1173R. 4427026 .
• Hunker CM . Rin1 regulates insulin receptor signal transduction pathways . Exp. Cell Res. . 312 . 7 . 1106–18 . 2006 . 16457816 . 10.1016/j.yexcr.2005.12.021 . Giambini H . Galvis A . Hall . J. . Kruk . I. . Veisaga . M.L. . Barbieri . M.A. .
• Beausoleil SA . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . Villén J . Gerber SA . Rush . John . Gygi . Steven P . 14294292 .
• Senda K . Analysis of RIN1 gene expression in colorectal cancer . Oncol. Rep. . 17 . 5 . 1171–5 . 2007 . 17390061 . 10.3892/or.17.5.1171. Goi T . Hirono Y . Katayama . K . Yamaguchi . A . free.
• Kong C, Su X, Chen PI, Stahl PD . Rin1 interacts with signal-transducing adaptor molecule (STAM) and mediates epidermal growth factor receptor trafficking and degradation . J. Biol. Chem. . 282 . 20 . 15294–301 . 2007 . 17403676 . 10.1074/jbc.M611538200 . free .

Notes and References

1. Han L, Wong D, Dhaka A, Afar D, White M, Xie W, Herschman H, Witte O, Colicelli J . Protein binding and signaling properties of RIN1 suggest a unique effector function . Proc Natl Acad Sci U S A . 94 . 10 . 4954–9 . Jun 1997 . 9144171 . 24612 . 10.1073/pnas.94.10.4954 . 1997PNAS...94.4954H . free .
2. Colicelli J, Nicolette C, Birchmeier C, Rodgers L, Riggs M, Wigler M . Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae . Proc Natl Acad Sci U S A . 88 . 7 . 2913–7 . May 1991 . 1849280 . 51350 . 10.1073/pnas.88.7.2913 . 1991PNAS...88.2913C . free .
3. Web site: Entrez Gene: RIN1 Ras and Rab interactor 1.
4. Mitin . Natalia Y . Ramocki Melissa B . Zullo Alfred J . Der Channing J . Konieczny Stephen F . Taparowsky Elizabeth J . May 2004 . Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization . J. Biol. Chem. . 279 . 21 . 22353–61 . United States. 0021-9258. 15031288 . 10.1074/jbc.M312867200 . free .
5. Han . L . Colicelli J . Mar 1995 . A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1 . Mol. Cell. Biol. . 15 . 3 . 1318–23 . UNITED STATES. 0270-7306. 7862125 . 230355 . 10.1128/mcb.15.3.1318.