Telomere-associated protein RIF1 explained

Telomere-associated protein RIF1 is a protein that in humans is encoded by the RIF1 gene.^{[1] [2] [3]}

RIF1 and RIF2 cap the chromosome ends (telomeres) in yeast.^[4] In higher eukaryotes, Rif1 is involved in DNA damage response, organisation of chromatin architecture and the regulation of replication timing. RIF1 has been shown to bind to RNA in the nucleus.^[5]

Further reading

• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA . A "double adaptor" method for improved shotgun library construction . Analytical Biochemistry . 236 . 1 . 107–13 . April 1996 . 8619474 . 10.1006/abio.1996.0138 .
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA . Large-scale concatenation cDNA sequencing . Genome Research . 7 . 4 . 353–8 . April 1997 . 9110174 . 139146 . 10.1101/gr.7.4.353 .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proceedings of the National Academy of Sciences of the United States of America . 101 . 33 . 12130–5 . August 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
• Xu L, Blackburn EH . Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules . The Journal of Cell Biology . 167 . 5 . 819–30 . December 2004 . 15583028 . 2172464 . 10.1083/jcb.200408181 .
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nature Biotechnology . 24 . 10 . 1285–92 . October 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . November 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Silverman J, Takai H, Buonomo SB, Eisenhaber F, de Lange T . Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint . Genes & Development . 18 . 17 . 2108–19 . September 2004 . 15342490 . 515289 . 10.1101/gad.1216004 .
2. Adams IR, McLaren A . Identification and characterisation of mRif1: a mouse telomere-associated protein highly expressed in germ cells and embryo-derived pluripotent stem cells . Developmental Dynamics . 229 . 4 . 733–44 . April 2004 . 15042697 . 10.1002/dvdy.10471 . 22138565 .
3. Web site: Entrez Gene: RIF1 RAP1 interacting factor homolog (yeast).
4. Ribeyre C, Shore D . Anticheckpoint pathways at telomeres in yeast . Nature Structural & Molecular Biology . 19 . 3 . 307–13 . 2012 . 22343724 . 10.1038/nsmb.2225 . 10636976 .
5. Conrad T, Albrecht AS, de Melo Costa VR, Sauer S, Meierhofer D, Ørom UA . Serial interactome capture of the human cell nucleus . Nature Communications . 7 . 11212 . 2016-01-01 . 27040163 . 10.1038/ncomms11212 . 4822031. 2016NatCo...711212C .