RIC8A explained

Resistance to inhibitors of cholinesterase-8A (Ric-8A), also known as Synembryn-A, is a protein that in humans is encoded by the RIC8A gene.^{[1] [2] [3]}

Interactions

RIC8A has been shown to interact with GNAO1,^[4] GNA13,^{[5] [4]} GNAQ,^{[4] [6]} GNAS complex locus,^[6] GNAI2,^[4] GNAI1^[4] and GNAI3.^[4]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination. . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Tall GG, Krumins AM, Gilman AG . Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor. . J. Biol. Chem. . 278 . 10 . 8356–62 . 2003 . 12509430 . 10.1074/jbc.M211862200 . free .
• Klattenhoff C, Montecino M, Soto X, etal . Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol. . J. Cell. Physiol. . 195 . 2 . 151–7 . 2003 . 12652642 . 10.1002/jcp.10300 . 10533/174200 . 84975473 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Wiemann S, Arlt D, Huber W, etal . From ORFeome to biology: a functional genomics pipeline. . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Mehrle A, Rosenfelder H, Schupp I, etal . The LIFEdb database in 2006. . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 .
• Nishimura A, Okamoto M, Sugawara Y, etal . Ric-8A potentiates Gq-mediated signal transduction by acting downstream of G protein-coupled receptor in intact cells. . Genes Cells . 11 . 5 . 487–98 . 2006 . 16629901 . 10.1111/j.1365-2443.2006.00959.x . 27425469 . free .
• Lim J, Hao T, Shaw C, etal . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . free .
• Wang SC, Lai HL, etal . Regulation of type V adenylate cyclase by Ric8a, a guanine nucleotide exchange factor. . Biochem J . 406 . 3 . 383–8 . 2007 . 17593019 . 10.1042/BJ20070512 . 2049038 .

Notes and References

1. Miller KG, Emerson MD, McManus JR, Rand JB . RIC-8 (Synembryn): a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system . Neuron . 27 . 2 . 289–99 . Sep 2000 . 10985349 . 4704990 . 10.1016/S0896-6273(00)00037-4 .
2. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs . Genome Res . 11 . 3 . 422–35 . Mar 2001 . 11230166 . 311072 . 10.1101/gr.GR1547R .
3. Web site: Entrez Gene: RIC8A resistance to inhibitors of cholinesterase 8 homolog A (C. elegans).
4. Tall . Gregory G . Krumins Andrejs M . Gilman Alfred G . Mar 2003 . Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor . J. Biol. Chem. . 278 . 10 . 8356–62 . United States. 0021-9258. 12509430 . 10.1074/jbc.M211862200 . free .
5. Wang L, Guo D, Xing B, Zhang JJ, Shu HB, Guo L, Huang XY . Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization . The Journal of Biological Chemistry . 286 . 35 . 31055–61 . September 2011 . 21771786 . 10.1074/jbc.M111.253427 . 3162464. free .
6. Klattenhoff . Carla . Montecino Martín . Soto Ximena . Guzmán Leonardo . Romo Ximena . García María Angeles . Mellstrom Britt . Naranjo José Ramón . Hinrichs María Victoria . Olate Juan . May 2003 . Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol . J. Cell. Physiol. . 195 . 2 . 151–7 . United States. 0021-9541. 12652642 . 10.1002/jcp.10300 . 10533/174200 . 84975473 . free .