RHBDF1 explained

Inactive rhomboid protein 1 (iRhom1) also known as rhomboid 5 homolog 1 or rhomboid family member 1 (RHBDF1) is a protein that in humans is encoded by the RHBDF1 gene.^{[1] [2] [3]} The alternative name iRhom1 has been proposed, in order to clarify that it is a catalytically inactive member of the rhomboid family of intramembrane serine proteases.^{[4] [5]}

Further reading

• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–45 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Daniels RJ . Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16 . Hum. Mol. Genet. . 10 . 4 . 339–352 . 2001 . 11157797 . 10.1093/hmg/10.4.339 . vanc. Peden JF . Lloyd C . 3 . Horsley . SW . Clark . K . Tufarelli . C . Kearney . L . Buckle . VJ . Doggett . NA . free .
• Suzuki Y . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–156 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . vanc. Yoshitomo-Nakagawa K . Maruyama K . 3 . Suyama . A . Sugano . S .
• Flint J . The relationship between chromosome structure and function at a human telomeric region . Nat. Genet. . 15 . 3 . 252–257 . 1997 . 9054936 . 10.1038/ng0397-252 . vanc. Thomas K . Micklem G . 3 . Raynham . Helen . Clark . Kevin . Doggett . Norman A. . Andrew . Andrew . Higgs . Douglas R. . 20630444 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–174 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .

Notes and References

1. Kielman MF, Smits R, Devi TS, Fodde R, Bernini LF . Homology of a 130-kb region enclosing the alpha-globin gene cluster, the alpha-locus controlling region, and two non-globin genes in human and mouse . Mamm Genome . 4 . 6 . 314–323 . Aug 1993 . 8318735 . 10.1007/BF00357090 . 24711956 .
2. Nakagawa T, Guichard A, Castro CP, Xiao Y, Rizen M, Zhang HZ, Hu D, Bang A, Helms J, Bier E, Derynck R . Characterization of a human rhomboid homolog, p100hRho/RHBDF1, which interacts with TGF-alpha family ligands . Dev Dyn . 233 . 4 . 1315–1331 . Jul 2005 . 15965977 . 10.1002/dvdy.20450 . 7770266 . free .
3. Web site: Entrez Gene: RHBDF1 rhomboid 5 homolog 1 (Drosophila).
4. Lemberg MK, Freeman M . Functional and evolutionary implications of enhanced genomic analysis of rhomboid intramembrane proteases . Genome Res. . 17 . 11 . 1634–46 . November 2007 . 17938163 . 2045146 . 10.1101/gr.6425307 .
5. Zettl M, Adrain C, Strisovsky K, Lastun V, Freeman M . Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling . Cell . 145 . 1 . 79–91 . April 2011 . 21439629 . 10.1016/j.cell.2011.02.047 . 3149277.