RGS7 explained

Regulator of G-protein signaling 7 is a protein that in humans is encoded by the RGS7 gene.^{[1] [2]}

RGS7 is highly enriched in the brain where it acts as a universal inhibitor of Gi/o-coupled GPCR. RGS7 is a GTPase-activating protein (GAP). It accelerates the GTP hydrolysis on G proteins determining their fast inactivation and acting as intracellular antagonists of GPCR signaling.^[3]

Interactions

RGS7 has been shown to interact with:

• GNB5,^{[4] [5]}
• GPR158,^[6]
• GPR179,
• PKD1,^[7] and
• SNAPAP.^[8]

Further reading

• Shuey DJ, Betty M, Jones PG, Khawaja XZ, Cockett MI . RGS7 attenuates signal transduction through the G(alpha q) family of heterotrimeric G proteins in mammalian cells . J. Neurochem. . 70 . 5 . 1964–72 . 1998 . 9572280 . 10.1046/j.1471-4159.1998.70051964.x . free .
• Levay K, Cabrera JL, Satpaev DK, Slepak VZ . Gβ5 prevents the RGS7-Gαo interaction through binding to a distinct Gγ-like domain found in RGS7 and other RGS proteins . Proc. Natl. Acad. Sci. U.S.A. . 96 . 5 . 2503–7 . 1999 . 10051672 . 26814 . 10.1073/pnas.96.5.2503 . 1999PNAS...96.2503L . free .
• Saitoh O, Kubo Y, Odagiri M, Ichikawa M, Yamagata K, Sekine T . RGS7 and RGS8 differentially accelerate G protein-mediated modulation of K+ currents . J. Biol. Chem. . 274 . 14 . 9899–904 . 1999 . 10092682 . 10.1074/jbc.274.14.9899 . free .
• Kim E, Arnould T, Sellin L, Benzing T, Comella N, Kocher O, Tsiokas L, Sukhatme VP, Walz G . Interaction between RGS7 and polycystin . Proc. Natl. Acad. Sci. U.S.A. . 96 . 11 . 6371–6 . 1999 . 10339594 . 26888 . 10.1073/pnas.96.11.6371 . 1999PNAS...96.6371K . free .
• Snow BE, Betts L, Mangion J, Sondek J, Siderovski DP . Fidelity of G protein β-subunit association by the G protein γ-subunit-like domains of RGS6, RGS7, and RGS11 . Proc. Natl. Acad. Sci. U.S.A. . 96 . 11 . 6489–94 . 1999 . 10339615 . 26909 . 10.1073/pnas.96.11.6489 . 1999PNAS...96.6489S . free .
• Posner BA, Gilman AG, Harris BA . Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways . J. Biol. Chem. . 274 . 43 . 31087–93 . 1999 . 10521509 . 10.1074/jbc.274.43.31087 . free .
• Benzing T, Yaffe MB, Arnould T, Sellin L, Schermer B, Schilling B, Schreiber R, Kunzelmann K, Leparc GG, Kim E, Walz G . 14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity . J. Biol. Chem. . 275 . 36 . 28167–72 . 2000 . 10862767 . 10.1074/jbc.M002905200 . free .
• Rose JJ, Taylor JB, Shi J, Cockett MI, Jones PG, Hepler JR . RGS7 is palmitoylated and exists as biochemically distinct forms . J. Neurochem. . 75 . 5 . 2103–12 . 2000 . 11032900 . 10.1046/j.1471-4159.2000.0752103.x . 20156736 . free .
• Zhang JH, Barr VA, Mo Y, Rojkova AM, Liu S, Simonds WF . Nuclear localization of G protein beta 5 and regulator of G protein signaling 7 in neurons and brain . J. Biol. Chem. . 276 . 13 . 10284–9 . 2001 . 11152459 . 10.1074/jbc.M009247200 . free .
• Benzing T, Köttgen M, Johnson M, Schermer B, Zentgraf H, Walz G, Kim E . Interaction of 14-3-3 protein with regulator of G protein signaling 7 is dynamically regulated by tumor necrosis factor-alpha . J. Biol. Chem. . 277 . 36 . 32954–62 . 2002 . 12077120 . 10.1074/jbc.M200859200 . free .
• Hunt RA, Edris W, Chanda PK, Nieuwenhuijsen B, Young KH . Snapin interacts with the N-terminus of regulator of G protein signaling 7 . Biochem. Biophys. Res. Commun. . 303 . 2 . 594–9 . 2003 . 12659861 . 10.1016/S0006-291X(03)00400-5 .
• Witherow DS, Tovey SC, Wang Q, Willars GB, Slepak VZ . G beta 5.RGS7 inhibits G alpha q-mediated signaling via a direct protein-protein interaction . J. Biol. Chem. . 278 . 23 . 21307–13 . 2003 . 12670932 . 10.1074/jbc.M212884200 . free .
• Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, Veenstra TD, Adkins JN, Pounds JG, Fagan R, Lobley A . The human plasma proteome: a nonredundant list developed by combination of four separate sources . Mol. Cell. Proteomics . 3 . 4 . 311–26 . 2004 . 14718574 . 10.1074/mcp.M300127-MCP200 . 7710900 . free .
• Takida S, Fischer CC, Wedegaertner PB . Palmitoylation and Plasma Membrane Targeting of RGS7 Are Promoted by αo . Mol. Pharmacol. . 67 . 1 . 132–9 . 2005 . 15496508 . 1405920 . 10.1124/mol.104.003418 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
• Drenan RM, Doupnik CA, Jayaraman M, Buchwalter AL, Kaltenbronn KM, Huettner JE, Linder ME, Blumer KJ . R7BP augments the function of RGS7*Gbeta5 complexes by a plasma membrane-targeting mechanism . J. Biol. Chem. . 281 . 38 . 28222–31 . 2006 . 16867977 . 10.1074/jbc.M604428200 . free .

Notes and References

1. Koelle MR, Horvitz HR . EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins . Cell . 84 . 1 . 115–25 . Feb 1996 . 8548815 . 10.1016/S0092-8674(00)80998-8 . 7815240 . free .
2. Web site: Entrez Gene: RGS7 regulator of G-protein signalling 7.
3. Anderson GR, Posokhova E, Martemyanov KA . The R7 RGS Protein Family: Multi-Subunit Regulators of Neuronal G Protein Signaling . . 54 . 1–3 . 33–46 . July 2009 . 19521673 . 2827338 . 10.1007/s12013-009-9052-9 .
4. Levay K, Cabrera JL, Satpaev DK, Slepak VZ . Gbeta5 prevents the RGS7-Galphao interaction through binding to a distinct Ggamma-like domain found in RGS7 and other RGS proteins . Proc. Natl. Acad. Sci. U.S.A. . 96 . 5 . 2503–7 . Mar 1999 . 10051672 . 26814 . 10.1073/pnas.96.5.2503. 1999PNAS...96.2503L . free .
5. Posner BA, Gilman AG, Harris BA . Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways . J. Biol. Chem. . 274 . 43 . 31087–93 . Oct 1999 . 10521509 . 10.1074/jbc.274.43.31087. free .
6. Orlandi C, Posokhova E, Masuho I, Ray TA, Hasan N, Gregg RG, Martemyanov KA . GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes . J. Cell Biol. . 197 . 6 . 711–9 . June 11, 2012 . 22689652 . 3373406 . 10.1083/jcb.201202123 .
7. Kim E, Arnould T, Sellin L, Benzing T, Comella N, Kocher O, Tsiokas L, Sukhatme VP, Walz G . Interaction between RGS7 and polycystin . Proc. Natl. Acad. Sci. U.S.A. . 96 . 11 . 6371–6 . May 1999 . 10339594 . 26888 . 10.1073/pnas.96.11.6371. 1999PNAS...96.6371K . free .
8. Hunt RA, Edris W, Chanda PK, Nieuwenhuijsen B, Young KH . Snapin interacts with the N-terminus of regulator of G protein signaling 7 . Biochem. Biophys. Res. Commun. . 303 . 2 . 594–9 . Apr 2003 . 12659861 . 10.1016/S0006-291X(03)00400-5.