RGS6 explained

Regulator of G-protein signaling 6 is a protein that in humans is encoded by the RGS6 gene.^{[1] [2] [3]}

Members of the RGS (regulator of G protein signaling) family have been shown to modulate the functioning of G proteins by activating the intrinsic GTPase activity of the alpha (guanine nucleotide-binding) subunits.[supplied by OMIM]

Interactions

RGS6 has been shown to interact with STMN2^[4] and DMAP1.

Further reading

• Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, Tsuda T, Mar L, Foncin JF, Bruni AC, Montesi MP, Sorbi S, Rainero I, Pinessi L, Nee L, Chumakov I, Pollen D, Brookes A, Sanseau P, Polinsky RJ, Wasco W, Da Silva HA, Haines JL, Perkicak-Vance MA, Tanzi RE, Roses AD, Fraser PE, Rommens JM, St George-Hyslop PH . Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease . Nature . 375 . 6534 . 754–60 . June 1995 . 7596406 . 10.1038/375754a0 . 1995Natur.375..754S . 4308372 .
• Snow BE, Betts L, Mangion J, Sondek J, Siderovski DP . Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11 . Proceedings of the National Academy of Sciences of the United States of America . 96 . 11 . 6489–94 . May 1999 . 10339615 . 26909 . 10.1073/pnas.96.11.6489 . 1999PNAS...96.6489S . free .
• Posner BA, Gilman AG, Harris BA . Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways . The Journal of Biological Chemistry . 274 . 43 . 31087–93 . October 1999 . 10521509 . 10.1074/jbc.274.43.31087 . free .
• Liu Z, Chatterjee TK, Fisher RA . RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6 . The Journal of Biological Chemistry . 277 . 40 . 37832–9 . October 2002 . 12140291 . 10.1074/jbc.M205908200 . free .
• Chatterjee TK, Fisher RA . Mild heat and proteotoxic stress promote unique subcellular trafficking and nucleolar accumulation of RGS6 and other RGS proteins. Role of the RGS domain in stress-induced trafficking of RGS proteins . The Journal of Biological Chemistry . 278 . 32 . 30272–82 . August 2003 . 12761220 . 10.1074/jbc.M212688200 . free .
• Chatterjee TK, Liu Z, Fisher RA . Human RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants . The Journal of Biological Chemistry . 278 . 32 . 30261–71 . August 2003 . 12761221 . 10.1074/jbc.M212687200 . free .

Notes and References

1. Seki N, Hattori A, Hayashi A, Kozuma S, Hori T, Saito T . The human regulator of G-protein signaling protein 6 gene (RGS6) maps between markers WI-5202 and D14S277 on chromosome 14q24.3 . Journal of Human Genetics . 44 . 2 . 138–40 . April 1999 . 10083744 . 10.1007/s100380050129 . free .
2. Liu Z, Fisher RA . RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity . The Journal of Biological Chemistry . 279 . 14 . 14120–8 . April 2004 . 14734556 . 10.1074/jbc.M309547200 . free .
3. Web site: Entrez Gene: RGS6 regulator of G-protein signalling 6.
4. Liu Z, Chatterjee TK, Fisher RA . RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6 . The Journal of Biological Chemistry . 277 . 40 . 37832–9 . October 2002 . 12140291 . 10.1074/jbc.M205908200 . free .