RGS3 explained

Regulator of G-protein signaling 3 is a protein that in humans is encoded by the RGS3 gene.^{[1] [2] [3]}

This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTP-ase activating protein which inhibits G-protein mediated signal transduction. The protein is largely cytosolic, but G-protein activation leads to translocation of this protein to the plasma membrane. A nuclear form of this protein has also been described, but its sequence has not been identified. Multiple alternatively spliced transcript variants have been described for this gene but the full-length nature of some transcripts is not yet known.

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Chatterjee TK, Eapen A, Kanis AB, Fisher RA . Genomic organization, 5'-flanking region, and chromosomal localization of the human RGS3 gene . Genomics . 45 . 2 . 429–33 . 1998 . 9344672 . 10.1006/geno.1997.4929 .
• Suzuki Y . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . Yoshitomo-Nakagawa K . Maruyama K . Suyama . A . Sugano . S .
• Dulin NO . RGS3 Inhibits G Protein-Mediated Signaling via Translocation to the Membrane and Binding to Gα11 . Mol. Cell. Biol. . 19 . 1 . 714–23 . 1999 . 9858594 . 10.1128/MCB.19.1.714. 83928 . Sorokin A . Reed E . Elliott . S . Kehrl . JH . Dunn . MJ .
• Dulin NO . Regulator of G protein signaling RGS3T is localized to the nucleus and induces apoptosis . J. Biol. Chem. . 275 . 28 . 21317–23 . 2000 . 10749886 . 10.1074/jbc.M910079199 . Pratt P . Tiruppathi C . Niu . J . Voyno-Yasenetskaya . T . Dunn . MJ . free.
• Shi CS . Regulator of G-protein signaling 3 (RGS3) inhibits Gbeta1gamma 2-induced inositol phosphate production, mitogen-activated protein kinase activation, and Akt activation . J. Biol. Chem. . 276 . 26 . 24293–300 . 2001 . 11294858 . 10.1074/jbc.M100089200 . Lee SB . Sinnarajah S . Dessauer . CW . Rhee . SG . Kehrl . JH . free.
• Lu Q, Sun EE, Klein RS, Flanagan JG . Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein and selectively inhibits G protein-coupled chemoattraction . Cell . 105 . 1 . 69–79 . 2001 . 11301003 . 10.1016/S0092-8674(01)00297-5 . 12590781 . free .
• Mittmann C . Evidence for a short form of RGS3 preferentially expressed in the human heart . Naunyn-Schmiedeberg's Arch. Pharmacol. . 363 . 4 . 456–63 . 2001 . 11330340 . 10.1007/s002100000376 . Schüler C . Chung CH . Not Available . Not Available . Not Available . Not Available . Not Available . Not Available . Not Available . Not Available . 36657400 .
• Niu J . RGS3 interacts with 14-3-3 via the N-terminal region distinct from the RGS (regulator of G-protein signalling) domain . Biochem. J. . 365 . Pt 3 . 677–84 . 2002 . 11985497 . 10.1042/BJ20020390 . 1222729 . Scheschonka A . Druey KM . Davis . Amanda . Reed . Eleanor . Kolenko . Vladimir . Bodnar . Richard . Voyno-Yasenetskaya . Tatyana . Du . Xiaoping .
• Kehrl JH . Additional 5' exons in the RGS3 locus generate multiple mRNA transcripts, one of which accounts for the origin of human PDZ-RGS3 . Genomics . 79 . 6 . 860–8 . 2002 . 12036301 . 10.1006/geno.2002.6773 . Srikumar D . Harrison K . Wilson . Gaye L. . Shi . Chong-Shan .
• Ikeda M . Transcriptional suppression of the estrogen receptor by truncated estrogen receptor-alpha . Horm. Metab. Res. . 34 . 8 . 425–30 . 2003 . 12198596 . 10.1055/s-2002-33599 . Okai M . Miyoshi T . Tone . S. . Minatogawa . Y. . 260167468 .
• Hirabayashi S, Ohno H, Iida J, Hata Y . C2PA is a nuclear protein implicated in the heat shock response . J. Cell. Biochem. . 87 . 1 . 65–74 . 2003 . 12210723 . 10.1002/jcb.10279 . 45812827 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . Suzuki Y . Nishikawa T . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Humphray SJ . DNA sequence and analysis of human chromosome 9 . Nature . 429 . 6990 . 369–74 . 2004 . 15164053 . 10.1038/nature02465 . 2734081 . Oliver K . Hunt AR . Plumb . R. W. . Loveland . J. E. . Howe . K. L. . Andrews . T. D. . Searle . S. . Hunt . S. E. . 2004Natur.429..369H .
• Tovey SC, Willars GB . Single-cell imaging of intracellular Ca2+ and phospholipase C activity reveals that RGS 2, 3, and 4 differentially regulate signaling via the Galphaq/11-linked muscarinic M3 receptor . Mol. Pharmacol. . 66 . 6 . 1453–64 . 2005 . 15383626 . 10.1124/mol.104.005827 . 24368533 .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Rual JF . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . Venkatesan K . Hao T . Hirozane-Kishikawa . Tomoko . Dricot . Amélie . Li . Ning . Berriz . Gabriel F. . Gibbons . Francis D. . Dreze . Matija . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Druey KM, Blumer KJ, Kang VH, Kehrl JH . Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family . Nature . 379 . 6567 . 742–6 . May 1996 . 8602223 . 10.1038/379742a0 . 1996Natur.379..742D . 4362632 .
2. Linares JL, Wendling C, Tomasetto C, Rio MC . C2PA, a new protein expressed during mouse spermatogenesis . FEBS Lett . 480 . 2–3 . 249–54 . Nov 2000 . 11034339 . 10.1016/S0014-5793(00)01942-6 . 12703563 .
3. Web site: Entrez Gene: RGS3 regulator of G-protein signalling 3.