RGS20 explained

Regulator of G-protein signaling 20 is a protein that in humans is encoded by the RGS20 gene.^{[1] [2] [3]}

Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.[supplied by OMIM]^[4]

In melanocytic cells RGS20 gene expression may be regulated by MITF.^[5]

Interactions

RGS20 has been shown to interact with GNAO1^[6] and GNAZ.^[7]

Further reading

• Barker SA, Wang J, Sierra DA, Ross EM . RGSZ1 and Ret RGS: two of several splice variants from the gene RGS20 . Genomics . 78 . 3 . 223–9 . December 2001 . 11735229 . 10.1006/geno.2001.6659 .
• Sierra DA, Gilbert DJ, Householder D, Grishin NV, Yu K, Ukidwe P, Barker SA, He W, Wensel TG, Otero G, Brown G, Copeland NG, Jenkins NA, Wilkie TM . 6 . Evolution of the regulators of G-protein signaling multigene family in mouse and human . Genomics . 79 . 2 . 177–85 . February 2002 . 11829488 . 10.1006/geno.2002.6693 . 16065132 .
• Nixon AB, Grenningloh G, Casey PJ . The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly . The Journal of Biological Chemistry . 277 . 20 . 18127–33 . May 2002 . 11882662 . 10.1074/jbc.M201065200 . free .
• Wang Y, Ho G, Zhang JJ, Nieuwenhuijsen B, Edris W, Chanda PK, Young KH . Regulator of G protein signaling Z1 (RGSZ1) interacts with Galpha i subunits and regulates Galpha i-mediated cell signaling . The Journal of Biological Chemistry . 277 . 50 . 48325–32 . December 2002 . 12379657 . 10.1074/jbc.M206116200 . free .
• Nagahama M, Usui S, Shinohara T, Yamaguchi T, Tani K, Tagaya M . Inactivation of Galpha(z) causes disassembly of the Golgi apparatus . Journal of Cell Science . 115 . Pt 23 . 4483–93 . December 2002 . 12414994 . 10.1242/jcs.00093 . free .
• Fischer T, De Vries L, Meerloo T, Farquhar MG . Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP . Proceedings of the National Academy of Sciences of the United States of America . 100 . 14 . 8270–5 . July 2003 . 12826607 . 166218 . 10.1073/pnas.1432965100 . 2003PNAS..100.8270F . free .
• Xu GY, Hum WT, Sukits SF, Hsiao CL, Liu Y, Malakian K, Monteiro K, Wolfrom S, Wang Y, Young KH, Moy FJ . 6 . 1H, 13C and 15N resonance assignments of human RGSZ1 . Journal of Biomolecular NMR . 28 . 4 . 409–10 . April 2004 . 14872136 . 10.1023/B:JNMR.0000015374.29659.f9 . 45949960 .
• Ajit SK, Ramineni S, Edris W, Hunt RA, Hum WT, Hepler JR, Young KH . RGSZ1 interacts with protein kinase C interacting protein PKCI-1 and modulates mu opioid receptor signaling . Cellular Signalling . 19 . 4 . 723–30 . April 2007 . 17126529 . 10.1016/j.cellsig.2006.09.008 .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . 6 . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .

Notes and References

1. Glick JL, Meigs TE, Miron A, Casey PJ . RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha . The Journal of Biological Chemistry . 273 . 40 . 26008–13 . October 1998 . 9748279 . 10.1074/jbc.273.40.26008 . free .
2. Wang J, Ducret A, Tu Y, Kozasa T, Aebersold R, Ross EM . RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz gtpase-activating protein subfamily . The Journal of Biological Chemistry . 273 . 40 . 26014–25 . October 1998 . 9748280 . 10.1074/jbc.273.40.26014 . free .
3. Web site: Entrez Gene: RGS20 regulator of G-protein signalling 20.
4. Web site: Entrez Gene: RGS20 regulator of G-protein signalling 20.
5. Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E . 6 . Novel MITF targets identified using a two-step DNA microarray strategy . Pigment Cell & Melanoma Research . 21 . 6 . 665–76 . December 2008 . 19067971 . 10.1111/j.1755-148X.2008.00505.x . 24698373 . free .
6. Pagano M, Jordan JD, Neves SR, Nguyen T, Iyengar R . Galphao/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways . Cellular Signalling . 20 . 6 . 1190–7 . June 2008 . 18407463 . 3107604 . 10.1016/j.cellsig.2008.02.008 .
7. Nagahama M, Usui S, Shinohara T, Yamaguchi T, Tani K, Tagaya M . Inactivation of Galpha(z) causes disassembly of the Golgi apparatus . Journal of Cell Science . 115 . Pt 23 . 4483–93 . December 2002 . 12414994 . 10.1242/jcs.00093 . free .