RGS13 explained

Regulator of G-protein signaling 13 (RGS13) is a protein that in humans is encoded by the RGS13 gene.^{[1] [2]}

RGS13 is a member of R4 subfamily of the Regulator of G protein signaling (RGS) protein family, whose members have only short peptide sequences flanking the RGS domain. RGS13 suppresses the immunoglobulin E- mediated allergic responses.^[3]

RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist.^[2]

Further reading

• Gregory SG . The DNA sequence and biological annotation of human chromosome 1 . Nature . 441 . 7091 . 315–321 . 2006 . 16710414 . 10.1038/nature04727 . Barlow KF . McLay KE . Kaul . R. . Swarbreck . D. . Dunham . A. . Scott . C. E. . Howe . K. L. . Woodfine . K. . 2006Natur.441..315G . free .
• Han JI, Huang NN, Kim DU, Kehrl JH . RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization . J. Leukoc. Biol. . 79 . 6 . 1357–1368 . 2006 . 16565322 . 10.1189/jlb.1105693 . 39672919 .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Islam TC . High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma . Leukemia . 17 . 9 . 1880–1890 . 2003 . 12970790 . 10.1038/sj.leu.2403057 . Asplund AC . Lindvall JM . Nygren . L . Liden . J . Kimby . E . Christensson . B . Smith . C I E . Sander . B . 4888825 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Sierra DA . Evolution of the regulators of G-protein signaling multigene family in mouse and human . Genomics . 79 . 2 . 177–185 . 2002 . 11829488 . 10.1006/geno.2002.6693 . Gilbert DJ . Householder D . Grishin . NV . Yu . K . Ukidwe . P . Barker . SA . He . W . Wensel . TG . 16065132 .
• Druey KM, Blumer KJ, Kang VH, Kehrl JH . Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family . Nature . 379 . 6567 . 742–746 . 1996 . 8602223 . 10.1038/379742a0 . 1996Natur.379..742D . 4362632 .

Notes and References

1. Johnson EN, Druey KM . Functional characterization of the G protein regulator RGS13 . J Biol Chem . 277 . 19 . 16768–16774 . May 2002 . 11875076 . 10.1074/jbc.M200751200 . free.
2. Web site: Entrez Gene: RGS13 regulator of G-protein signalling 13.
3. Bansal G, Xie Z, Rao S, Nocka KH, Druey KM . Suppression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13 . Nat. Immunol. . 9 . 1 . 73–80 . 2008 . 18026105 . 10.1038/ni1533 . 2387203 .