RGS12 explained

Regulator of G-protein signaling 12 is a protein that in humans is encoded by the RGS12 gene.^{[1] [2]}

This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined.^[2]

Interactions

RGS12 has been shown to interact with GNAI1,^[3] GNAI3,^[3] and the kappa opioid receptor.^[4]

Further reading

• Frohme M, Scharm B, Delius H, etal . Use of representational difference analysis and cDNA arrays for transcriptional profiling of tumor tissue. . Ann. N. Y. Acad. Sci. . 910 . 1. 85–104; discussion 104–5 . 2000 . 10911908 . 10.1111/j.1749-6632.2000.tb06703.x . 2000NYASA.910...85F . 25399395 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Snow BE, Antonio L, Suggs S, etal . Molecular cloning and expression analysis of rat Rgs12 and Rgs14. . Biochem. Biophys. Res. Commun. . 233 . 3 . 770–7 . 1997 . 9168931 . 10.1006/bbrc.1997.6537 .
• Chatterjee TK, Fisher RA . Novel alternative splicing and nuclear localization of human RGS12 gene products. . J. Biol. Chem. . 275 . 38 . 29660–71 . 2000 . 10869340 . 10.1074/jbc.M000330200 . free .
• Schiff ML, Siderovski DP, Jordan JD, etal . Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel. . Nature . 408 . 6813 . 723–7 . 2001 . 11130074 . 10.1038/35047093 . 205011654 .
• Kimple RJ, De Vries L, Tronchère H, etal . RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity. . J. Biol. Chem. . 276 . 31 . 29275–81 . 2001 . 11387333 . 10.1074/jbc.M103208200 . free .
• Book: Snow BE, Brothers GM, Siderovski DP . G Protein Pathways, Part B: G Proteins and their Regulators . Molecular Cloning of Regulators of G-Protein Signaling Family Members and Characterization of Binding Specificity of RGS 12 PDZ Domain . 344 . 740–61 . 2002 . 11771424 . 10.1016/S0076-6879(02)44752-0 . Methods in Enzymology . 978-0-12-182245-3 .
• Sierra DA, Gilbert DJ, Householder D, etal . Evolution of the regulators of G-protein signaling multigene family in mouse and human. . Genomics . 79 . 2 . 177–85 . 2002 . 11829488 . 10.1006/geno.2002.6693 . 16065132 .
• Chatterjee TK, Fisher RA . RGS12TS-S localizes at nuclear matrix-associated subnuclear structures and represses transcription: structural requirements for subnuclear targeting and transcriptional repression. . Mol. Cell. Biol. . 22 . 12 . 4334–45 . 2002 . 12024043 . 10.1128/MCB.22.12.4334-4345.2002 . 133853 .
• Potocnik U, Glavac D, Ravnik-Glavac M . Identification of novel genes with somatic frameshift mutations within coding mononucleotide repeats in colorectal tumors with high microsatellite instability. . Genes Chromosomes Cancer . 36 . 1 . 48–56 . 2003 . 12461749 . 10.1002/gcc.10141 . 30132562 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Jin J, Smith FD, Stark C, etal . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. . Curr. Biol. . 14 . 16 . 1436–50 . 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . 2371325 . free . 2004CBio...14.1436J .
• Yang S, Li YP . RGS12 is essential for RANKL-evoked signaling for terminal differentiation of osteoclasts in vitro. . J. Bone Miner. Res. . 22 . 1 . 45–54 . 2007 . 17042716 . 10.1359/jbmr.061007 . 3559086.
• Gross . J. D.. Kaski . S. W.. Schroer . A. B.. Wix . K. A.. Siderovski . D. P.. Setola . V.. Regulator of G protein signaling-12 modulates the dopamine transporter in ventral striatum and locomotor responses to psychostimulants. J. Psychopharmacol.. 32. 2. 191–203. 2018. 29364035. 5942192 . 10.1177/0269881117742100.
• Gross. Joshua D.. Kaski. Shane W.. Schmidt. Karl T.. Cogan. Elizabeth S.. Boyt. Kristen M.. Wix. Kim. Schroer. Adam B.. McElligott. Zoe A.. Siderovski. David P.. 2019-05-29. Role of RGS12 in the differential regulation of kappa opioid receptor-dependent signaling and behavior. Neuropsychopharmacology. 44. 10. 1728–1741. 10.1038/s41386-019-0423-7. 1740-634X. 31141817. 6785087.
• Schroer . AB . Mohamed . JS . Willard . MD . Setola . V . Oestreich . E . Siderovski . DP . A role for Regulator of G protein Signaling-12 (RGS12) in the balance between myoblast proliferation and differentiation. . PLOS ONE . 2019 . 14 . 8 . e0216167 . 10.1371/journal.pone.0216167 . 31408461. 6691989 . 2019PLoSO..1416167S . free .

Notes and References

1. Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP . GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain . J Biol Chem . 273 . 28 . 17749–55 . August 1998 . 9651375 . 10.1074/jbc.273.28.17749 . free .
2. Web site: Entrez Gene: RGS12 regulator of G-protein signalling 12.
3. Kimple . R J . De Vries L . Tronchère H . Behe C I . Morris R A . Gist Farquhar M . Siderovski D P . August 2001 . RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity . J. Biol. Chem. . 276 . 31 . 29275–81 . 0021-9258. 11387333 . 10.1074/jbc.M103208200 . free .
4. Gross . JD . Kaski . SW . Schmidt . KT . Cogan . ES . Boyt . KM . Wix . K . Schroer . AB . McElligott . ZA . Siderovski . DP . Setola . V . Role of RGS12 in the differential regulation of kappa opioid receptor-dependent signaling and behavior. . Neuropsychopharmacology . September 2019 . 44 . 10 . 1728–1741 . 10.1038/s41386-019-0423-7 . 31141817. 6785087 .