RGS11 explained

Regulator of G-protein signaling 11 is a protein that in humans is encoded by the RGS11 gene.^{[1] [2]}

The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.^[3]

Further reading

• Martin J, Han C, Gordon LA, etal . The sequence and analysis of duplication-rich human chromosome 16. . Nature . 432 . 7020 . 988–94 . 2005 . 15616553 . 10.1038/nature03187 . 2004Natur.432..988M . 4362044 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Sierra DA, Gilbert DJ, Householder D, etal . Evolution of the regulators of G-protein signaling multigene family in mouse and human. . Genomics . 79 . 2 . 177–85 . 2002 . 11829488 . 10.1006/geno.2002.6693 . 16065132 .
• Daniels RJ, Peden JF, Lloyd C, etal . Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. . Hum. Mol. Genet. . 10 . 4 . 339–52 . 2001 . 11157797 . 10.1093/hmg/10.4.339 . free .
• Snow BE, Betts L, Mangion J, etal . Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11. . Proc. Natl. Acad. Sci. U.S.A. . 96 . 11 . 6489–94 . 1999 . 10339615 . 10.1073/pnas.96.11.6489 . 26909 . 1999PNAS...96.6489S . free .
• Gold SJ, Ni YG, Dohlman HG, Nestler EJ . Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain. . J. Neurosci. . 17 . 20 . 8024–37 . 1997 . 9315921 . 6793903 . 10.1523/JNEUROSCI.17-20-08024.1997.

Notes and References

1. Snow BE, Krumins AM, Brothers GM, Lee SF, Wall MA, Chung S, Mangion J, Arya S, Gilman AG, Siderovski DP . A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits . Proc Natl Acad Sci U S A . 95 . 22 . 13307–12 . Nov 1998 . 9789084 . 23793 . 10.1073/pnas.95.22.13307 . 1998PNAS...9513307S . free .
2. Web site: Entrez Gene: RGS11 regulator of G-protein signalling 11.
3. Web site: Entrez Gene: RGS11 regulator of G-protein signalling 11.