RGS10 explained

Regulator of G-protein signaling 10 is a protein that in humans is encoded by the RGS10 gene.^{[1] [2]}

Function

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene.^[2]

Interactions

RGS10 has been shown to interact with SAP18^[3] and GNAI3.

Further reading

• Popov S, Yu K, Kozasa T, Wilkie TM . The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro . Proceedings of the National Academy of Sciences of the United States of America . 94 . 14 . 7216–20 . Jul 1997 . 9207071 . 23796 . 10.1073/pnas.94.14.7216 . 1997PNAS...94.7216P . free .
• Tu Y, Wang J, Ross EM . Inhibition of brain Gz GAP and other RGS proteins by palmitoylation of G protein alpha subunits . Science . 278 . 5340 . 1132–5 . Nov 1997 . 9353196 . 10.1126/science.278.5340.1132 .
• Tu Y, Popov S, Slaughter C, Ross EM . Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10 . The Journal of Biological Chemistry . 274 . 53 . 38260–7 . Dec 1999 . 10608901 . 10.1074/jbc.274.53.38260 . free .
• John R. Falck. Popov SG, Krishna UM, Falck JR, Wilkie TM . Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity . The Journal of Biological Chemistry . 275 . 25 . 18962–8 . Jun 2000 . 10747990 . 10.1074/jbc.M001128200 . free .
• Chatterjee TK, Fisher RA . Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs . The Journal of Biological Chemistry . 275 . 31 . 24013–21 . Aug 2000 . 10791963 . 10.1074/jbc.M002082200 . free .
• Burgon PG, Lee WL, Nixon AB, Peralta EG, Casey PJ . Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10) . The Journal of Biological Chemistry . 276 . 35 . 32828–34 . Aug 2001 . 11443111 . 10.1074/jbc.M100960200 . free .
• Gagnon AW, Murray DL, Leadley RJ . Cloning and characterization of a novel regulator of G protein signalling in human platelets . Cellular Signalling . 14 . 7 . 595–606 . Jul 2002 . 11955952 . 10.1016/S0898-6568(02)00012-8 .
• Castro-Fernández C, Conn PM . Regulation of the gonadotropin-releasing hormone receptor (GnRHR) by RGS proteins: role of the GnRHR carboxyl-terminus . Molecular and Cellular Endocrinology . 191 . 2 . 149–56 . Jun 2002 . 12062898 . 10.1016/S0303-7207(02)00082-5 . 36812170 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS . Transcriptome analysis of human gastric cancer . Mammalian Genome . 16 . 12 . 942–54 . Dec 2005 . 16341674 . 10.1007/s00335-005-0075-2 . 69278 .
• Lee HK, Rhee KH, Kim CW, Hwang KY, Kim EE . Crystallization and preliminary X-ray crystallographic analysis of human RGS10 complexed with Galphai3 . Acta Crystallographica Section F . 61 . Pt 9 . 831–3 . Sep 2005 . 16511171 . 1978115 . 10.1107/S1744309105023602 .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .

Notes and References

1. Hunt TW, Fields TA, Casey PJ, Peralta EG . RGS10 is a selective activator of G alpha i GTPase activity . Nature . 383 . 6596 . 175–7 . Sep 1996 . 8774883 . 10.1038/383175a0 . 1996Natur.383..175H . 4318445 .
2. Web site: Entrez Gene: RGS10 regulator of G-protein signalling 10.
3. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .